Ignite Creation Date:
2024-05-06 @ 6:46 PM
Last Modification Date:
2024-10-26 @ 2:54 PM
Study NCT ID:
NCT05771337
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-03-16
First Post:
2023-03-05
Brief Title:
Circular RNA and Chemerin in Breast Cancer Patient
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Circular RNA and Chemerin in Blood of Breast Cancer Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aimed to evaluate the role of serum chemerin as a biomarker of breast cancer
and To investigate the diagnostic value of hsa_circ_0001785 Circ-ELP3 and hsa_circ_100219 Circ-FAF1 in serum samples of breast cancer patients to find out whether these circRNAs can utilize as a diagnostic and prognostic biomarker for human breast cancer assessment and make Correlation between serum chemerin levels serum Circ-FAF1 serum CircELP3 and classical tumor markers CEA CA15-3
andTo elucidate if there is a difference between metastatic and non-metastatic cases as regard serum chemerin levels serum Circ-FAF1 or Circ-ELP3
and To investigate the diagnostic value of hsa_circ_0001785 Circ-ELP3 and hsa_circ_100219 Circ-FAF1 in serum samples of breast cancer patients to find out whether these circRNAs can utilize as a diagnostic and prognostic biomarker for human breast cancer assessment and make Correlation between serum chemerin levels serum Circ-FAF1 serum CircELP3 and classical tumor markers CEA CA15-3
andTo elucidate if there is a difference between metastatic and non-metastatic cases as regard serum chemerin levels serum Circ-FAF1 or Circ-ELP3
Detailed Description:
Breast cancer is the most common cancer among women and despite advances in therapy over the past few decades drug resistance recurrence metastasis and the heterogeneity of the cancer continue to be a problem in successful management of the diseasesHong et al 2019
Circular RNAs CircRNAs are single-stranded covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammalsZhou et al 3 2020 circRNAs can be divided into two categories including coding and noncoding circRNAsLi et al 2019 A new subtype of RNAs is circular RNAs single-strand RNA molecules with less than 100 to more than 4000 nucleotides Lu et al 2016 and a covalently closedloop structure These molecules are produced through a backsplicing mechanism in which the downstream 5-end of the splice donor joins the upstream 3-end splice acceptor and forms a product with a circular structure wang et al 2017
Chemerin is a leukocyte chemoattractant widely expressed in many tissues and is known to recruit innate leukocytes
Recently more and more studies focus on the relationship between chemerin and cancers and found that chemerin acts an essential role in cancersShin et al2018 Chemerin expression is different depending on the tumor type Zhang Y et al 2013 the clinical significance of chemerin in breast cancer has been only reported by a very limited number of studies EL Sagheer et al2018
Circular RNAs CircRNAs are single-stranded covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammalsZhou et al 3 2020 circRNAs can be divided into two categories including coding and noncoding circRNAsLi et al 2019 A new subtype of RNAs is circular RNAs single-strand RNA molecules with less than 100 to more than 4000 nucleotides Lu et al 2016 and a covalently closedloop structure These molecules are produced through a backsplicing mechanism in which the downstream 5-end of the splice donor joins the upstream 3-end splice acceptor and forms a product with a circular structure wang et al 2017
Chemerin is a leukocyte chemoattractant widely expressed in many tissues and is known to recruit innate leukocytes
Recently more and more studies focus on the relationship between chemerin and cancers and found that chemerin acts an essential role in cancersShin et al2018 Chemerin expression is different depending on the tumor type Zhang Y et al 2013 the clinical significance of chemerin in breast cancer has been only reported by a very limited number of studies EL Sagheer et al2018
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None