Ignite Creation Date:
2024-05-06 @ 6:46 PM
Last Modification Date:
2025-12-17 @ 5:19 AM
Study NCT ID:
NCT05771337
Status:
None
Last Update Posted:
2023-03-16 00:00:00
First Post:
2023-03-05 00:00:00
Brief Title:
Circular RNA and Chemerin in Breast Cancer Patient
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Circular RNA and Chemerin in Blood of Breast Cancer Patients
Status:
None
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Breast cancer is the most common cancer among women and despite advances in therapy over the past few decades, drug resistance, recurrence, metastasis and the heterogeneity of the cancer continue to be a problem in successful management of the diseases(Hong et al ,2019) .
Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals(Zhou et al 3 .,2020). circRNAs can be divided into two categories including coding and noncoding circRNAs(Li et al., 2019) A new subtype of RNAs is circular RNAs, single-strand RNA molecules with less than 100 to more than 4,000 nucleotides (Lu et al., 2016) and a covalently closedloop structure. These molecules are produced through a backsplicing mechanism, in which the downstream 5'-end of the splice donor joins the upstream 3'-end splice acceptor and forms a product with a circular structure (wang et al., 2017).
Chemerin is a leukocyte chemoattractant widely expressed in many tissues and is known to recruit innate leukocytes.
Recently, more and more studies focus on the relationship between chemerin and cancers and found that chemerin acts an essential role in cancers.(Shin et al,2018) Chemerin expression is different depending on the tumor type (Zhang Y et al, 2013) the clinical significance of chemerin in breast cancer has been only reported by a very limited number of studies (EL Sagheer et al,2018).
Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals(Zhou et al 3 .,2020). circRNAs can be divided into two categories including coding and noncoding circRNAs(Li et al., 2019) A new subtype of RNAs is circular RNAs, single-strand RNA molecules with less than 100 to more than 4,000 nucleotides (Lu et al., 2016) and a covalently closedloop structure. These molecules are produced through a backsplicing mechanism, in which the downstream 5'-end of the splice donor joins the upstream 3'-end splice acceptor and forms a product with a circular structure (wang et al., 2017).
Chemerin is a leukocyte chemoattractant widely expressed in many tissues and is known to recruit innate leukocytes.
Recently, more and more studies focus on the relationship between chemerin and cancers and found that chemerin acts an essential role in cancers.(Shin et al,2018) Chemerin expression is different depending on the tumor type (Zhang Y et al, 2013) the clinical significance of chemerin in breast cancer has been only reported by a very limited number of studies (EL Sagheer et al,2018).
Detailed Description:
Breast cancer is the most common cancer among women and despite advances in therapy over the past few decades drug resistance recurrence metastasis and the heterogeneity of the cancer continue to be a problem in successful management of the diseasesHong et al 2019
Circular RNAs CircRNAs are single-stranded covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammalsZhou et al 3 2020 circRNAs can be divided into two categories including coding and noncoding circRNAsLi et al 2019 A new subtype of RNAs is circular RNAs single-strand RNA molecules with less than 100 to more than 4000 nucleotides Lu et al 2016 and a covalently closedloop structure These molecules are produced through a backsplicing mechanism in which the downstream 5-end of the splice donor joins the upstream 3-end splice acceptor and forms a product with a circular structure wang et al 2017
Chemerin is a leukocyte chemoattractant widely expressed in many tissues and is known to recruit innate leukocytes
Recently more and more studies focus on the relationship between chemerin and cancers and found that chemerin acts an essential role in cancersShin et al2018 Chemerin expression is different depending on the tumor type Zhang Y et al 2013 the clinical significance of chemerin in breast cancer has been only reported by a very limited number of studies EL Sagheer et al2018
Circular RNAs CircRNAs are single-stranded covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammalsZhou et al 3 2020 circRNAs can be divided into two categories including coding and noncoding circRNAsLi et al 2019 A new subtype of RNAs is circular RNAs single-strand RNA molecules with less than 100 to more than 4000 nucleotides Lu et al 2016 and a covalently closedloop structure These molecules are produced through a backsplicing mechanism in which the downstream 5-end of the splice donor joins the upstream 3-end splice acceptor and forms a product with a circular structure wang et al 2017
Chemerin is a leukocyte chemoattractant widely expressed in many tissues and is known to recruit innate leukocytes
Recently more and more studies focus on the relationship between chemerin and cancers and found that chemerin acts an essential role in cancersShin et al2018 Chemerin expression is different depending on the tumor type Zhang Y et al 2013 the clinical significance of chemerin in breast cancer has been only reported by a very limited number of studies EL Sagheer et al2018
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None