Ignite Creation Date:
2024-05-06 @ 6:45 PM
Last Modification Date:
2024-10-26 @ 2:54 PM
Study NCT ID:
NCT05773001
Status:
RECRUITING
Last Update Posted:
2024-06-20
First Post:
2023-03-03
Brief Title:
Macrophage Regulation of Ozone-Induced Lung Inflammation
Sponsor:
Robert Tighe MD
Organization:
Duke University
Study Overview
Official Title:
Macrophage Regulation of Ozone-Induced Lung Inflammation
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MOLI
Brief Summary:
The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures
Detailed Description:
Study participants will undergo a 1-day screening that includes a blood draw and breathing testing return for a two-day series of testing to include blood draw and brief breathing test before and after an inhaled challenge with either filtered air FA or ozone O3 Participants return the next day for a brief breathing test a blood draw and a procedure called bronchoscopy to evaluate the lung after the challenge
Participants then return 18 - 20 days later to repeat the two-day series of testing to be challenged with the exposure not received on the first series FA or O3 Each visit will take about 3 - 35 hours Follow-up phone calls from the study team will occur at 24 hours after each 2-day test series
Total study duration is about one to one-and a half months
Participants then return 18 - 20 days later to repeat the two-day series of testing to be challenged with the exposure not received on the first series FA or O3 Each visit will take about 3 - 35 hours Follow-up phone calls from the study team will occur at 24 hours after each 2-day test series
Total study duration is about one to one-and a half months
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01ES034350-01 | NIH | None | httpsreporternihgovquickSearch1R01ES034350-01 |