Ignite Creation Date:
2024-05-06 @ 6:45 PM
Last Modification Date:
2024-10-26 @ 2:54 PM
Study NCT ID:
NCT05772312
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-03-19
First Post:
2023-03-06
Brief Title:
Quality of Life of Patients With Bone Tumor of the Lower Limbs Treated With Salvage Surgery
Sponsor:
Istituto Ortopedico Rizzoli
Organization:
Istituto Ortopedico Rizzoli
Study Overview
Official Title:
Quality of Life of Patients With Bone Tumors of the Lower Limbs Treated With Salvage Surgery a Long-term Follow-up Study
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Onco-QoL
Brief Summary:
The aim of the study is to describe through a minimum follow-up of 18 months the quality of life of patients undergoing salvage surgery of lower limb for musculoskeletal tumors and to identify possible prognostic factor correlated
Quality of life will be evaluated with Bt-DUX Btbone tumor
Quality of life will be evaluated with Bt-DUX Btbone tumor
Detailed Description:
Musculoskeletal cancers are extremely rare accounting for approximately 02 of all cancers 14 are bone sarcomas which occur more frequently in children and adolescents The most frequent location is at the metaphyseal level of the femur 42 and tibia 19
Surgery and chemotherapy treatments have significantly increased survival rates for patients with bone tumor Early rehabilitation of these patients after surgery is to promote recovery as early as possible with maximum autonomy In literature data about the association between the early functional recovery and quality of life are few Long-term studies about the quality of life of these patients are so necessary The quality of life is measured with several scale that included a set of non-specific domains for bone tumor patients For this reason a specific assessment scale was introduced and validated in 2013 to measure the quality of life of patients with bone cancer of the lower limbs the Bt-DUX scale
In 2019 the Bt-DUX scale was validated in Italian
Considering the rarity of the disease and verified that the number of patients treated in 2019 and 2020 is 30 and 32 respectively the investigators estimate to enroll from January 2019 to June 2023 a number of patients equal to 100 considering a rejection rate of 10
Patient characteristics and scale values will be summarized using descriptive statistics absolute frequencies and percentages for categorical variables mean and standard deviation or median and interquartile range for continuous variables
The variables collected will be age sex diagnosis type of surgery site of tumour complication infection relapses metastasis TESS Toronto Extremity Salvage Score at 3 and 6 months knee or hip flexion at 3 and 6 months quadriceps or hip abductor strength at 3 and 6 months and time up and go at 3 and 6 months
The relationship of patient characteristics with functional outcomes and quality of life will be investigated using multiple regression models while the correlation between measures of functional recovery will be analyzed using Pearsons or Spearmans correlation coefficient depending on the distribution of the variables considered
The aim of the study is to describe the quality of life of patients undergoing salvage surgery of the lower limb for musculoskeletal tumors with a long follow-up and to investigate the association with early functional recovery
Surgery and chemotherapy treatments have significantly increased survival rates for patients with bone tumor Early rehabilitation of these patients after surgery is to promote recovery as early as possible with maximum autonomy In literature data about the association between the early functional recovery and quality of life are few Long-term studies about the quality of life of these patients are so necessary The quality of life is measured with several scale that included a set of non-specific domains for bone tumor patients For this reason a specific assessment scale was introduced and validated in 2013 to measure the quality of life of patients with bone cancer of the lower limbs the Bt-DUX scale
In 2019 the Bt-DUX scale was validated in Italian
Considering the rarity of the disease and verified that the number of patients treated in 2019 and 2020 is 30 and 32 respectively the investigators estimate to enroll from January 2019 to June 2023 a number of patients equal to 100 considering a rejection rate of 10
Patient characteristics and scale values will be summarized using descriptive statistics absolute frequencies and percentages for categorical variables mean and standard deviation or median and interquartile range for continuous variables
The variables collected will be age sex diagnosis type of surgery site of tumour complication infection relapses metastasis TESS Toronto Extremity Salvage Score at 3 and 6 months knee or hip flexion at 3 and 6 months quadriceps or hip abductor strength at 3 and 6 months and time up and go at 3 and 6 months
The relationship of patient characteristics with functional outcomes and quality of life will be investigated using multiple regression models while the correlation between measures of functional recovery will be analyzed using Pearsons or Spearmans correlation coefficient depending on the distribution of the variables considered
The aim of the study is to describe the quality of life of patients undergoing salvage surgery of the lower limb for musculoskeletal tumors with a long follow-up and to investigate the association with early functional recovery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None