Ignite Creation Date:
2024-05-06 @ 6:45 PM
Last Modification Date:
2024-10-26 @ 2:54 PM
Study NCT ID:
NCT05778955
Status:
RECRUITING
Last Update Posted:
2023-03-22
First Post:
2023-02-15
Brief Title:
Study on Dynamic CtDNA Analysis in Pediatric Soft Tissue Sarcoma
Sponsor:
Sun Yat-sen University
Organization:
Sun Yat-sen University
Study Overview
Official Title:
The Significance of Dynamic Monitoring of ctDNA in Pediatric Soft Tissue Sarcoma
Status:
RECRUITING
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pediatric soft tissue sarcoma is made up of different subtypes some of which have distinct genetic alterations Fusion variants were found in about 43 of bone and soft tissue sarcoma samples Ewing sarcoma is characterized by recurrent chromosome translocation with up to 95 of cases showing EWS-ETS translocation The genetic features of the tumor can change as it spreads or shrinks and can also be influenced by treatment
To better understand treatment response and predict relapse early our study collects liquid samples such as blood bone marrow or cerebrospinal fluid at various points during treatment We then use next-generation sequencing to dynamically monitor the unique genetic profile of the tumor Additionally our research may identify new genetic targets and suggest potential treatment options
To better understand treatment response and predict relapse early our study collects liquid samples such as blood bone marrow or cerebrospinal fluid at various points during treatment We then use next-generation sequencing to dynamically monitor the unique genetic profile of the tumor Additionally our research may identify new genetic targets and suggest potential treatment options
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None