Ignite Creation Date:
2024-05-06 @ 6:45 PM
Last Modification Date:
2024-10-26 @ 2:54 PM
Study NCT ID:
NCT05775536
Status:
COMPLETED
Last Update Posted:
2023-03-20
First Post:
2023-02-24
Brief Title:
Detection of Acetylsalicylic Acid and Omega-3 Fatty Acids in Schirmers Test Strips Using Mass Spectrometry
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Detection of Acetylsalicylic Acid and Omega-3 Fatty Acids in Schirmers Test Strips Using Mass Spectrometry and Correlations With Tear Film and Blood Flow Parameters in Healthy Adults an Open-label Pilot Study
Status:
COMPLETED
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Evaluation of tear fluid production using Schirmers tests is a well-known and frequently used examination method in ophthalmology Schirmers test objectively indicates the tear fluid production over five minutes by insertion of a filter paper strip in the lower conjunctival fornix Commonly this method is used to quantify tear fluid production but not tear fluid composition The development of novel very precise analytical methods opens up new possibilities in the use and application of Schirmers test strips A recently introduced analytical method is mass spectrometry This method allows the detection and quantification of proteins lipids and metabolites in very low amounts of samples Whether systemically ingested agents such as omega-3 fatty acids or acetylsalicylic acid can be detected in tear fluid using this method remains unclear The aim of this study is to investigate the detectability of 2 different agents acetylsalicylic acid and omega-3 fatty acids in Schirmers test strips from healthy subjects after intake for 1 week by use of untargeted mass spectrometry Participating healthy subjects will receive either acetylsalicylic acid or omega-3 fatty acids
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None