Ignite Creation Date:
2024-05-06 @ 6:44 PM
Last Modification Date:
2024-10-26 @ 2:53 PM
Study NCT ID:
NCT05760625
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2023-03-08
First Post:
2023-02-26
Brief Title:
Gender Differences and Features of the Clinical Course of Primary Headaches
Sponsor:
Tashkent Medical Academy
Organization:
Tashkent Medical Academy
Study Overview
Official Title:
Gender Differences and Features of the Clinical Course of Primary Headaches
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2023-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The pathophysiological mechanisms that underlie primary headache disorders such as migraine and cluster headache CH are complex and not yet fully clarified While there is today little doubt that activation of the trigeminovascular system TGVS is responsible for the headache pain the primary mechanisms probably centrally mediated leading to its activation and the generation of pain are still largely obscure The trigeminal system is supposed to play a central role not only in migraine but also in cluster headache pathology In vitro studies have demonstrated the expression of BDNF in trigeminal ganglion neurons BDNF release is induced by trigeminal stimulation and nociceptive inputs BDNF is a member of the neurotrophin family and has been recognized as an important modulator of nociceptive pathways Interestingly BDNF is co-expressed with CGRP in trigeminal ganglion neurons CGRP is one of the key molecules in migraine and cluster headache pathogenesis BDNF is an important marker of neuronal plasticity It has also been associated with pain processing Increased BDNF levels are observed in chronic pain syndromes In order to understand the role of BDNF associated with other factors such as gender on headache attacks we aimed to determine whether migraine and cluster headache is correlated with brain derived neurotrophic factor BDNF level gender and age
Detailed Description:
Patients will recruite among those attending the Clinic of Tashkent Medical Academy Uzbekistan Three groups of headache patients will be enrolled in this prospective study patients with episodic migraine with and without aura episodic cluster headache and frequent episodic tension-type headache according to the current criteria of the International Headache Society In migraineurs venous blood samples will be collected twice outside and during migraine attacks prior to pain medication In cluster headache patients serum samples will be collected in and outside cluster bout Analysis of BDNF will performed using enzyme-linked immunosorbent assay technique In patients with tension-type headache outside attack and healthy controls one single blood sample will takePatients with a history of cardiovascular disease major depression hypertension drug or alcohol abuse or other apparent diseases will be excluded from the study The research will comprise 120 patients males and females suffering from primary headache At the moment we started collecting patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None