Ignite Creation Date:
2024-05-06 @ 6:44 PM
Last Modification Date:
2024-10-26 @ 2:53 PM
Study NCT ID:
NCT05766345
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-04-10
First Post:
2023-01-16
Brief Title:
BCG-induced Epigenetic Modifications in the NEXT Generation
Sponsor:
Radboud University Medical Center
Organization:
Radboud University Medical Center
Study Overview
Official Title:
BCG-induced Epigenetic Modifications in the NEXT Generation
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NEXT
Brief Summary:
Non-specific protective effects resulting from the BCG vaccine appear to be paternally inheritable Since the BCG vaccine is known to induce trained immunity epigenetics might explain the fathers contribution to the immune profile of their offspring Epigenetic inheritance in mice has recently been demonstrated but is not established in humans yet By studying the DNA methylation profile of sperm cells after BCG vaccination we aim to gain insight into the possibility of epigenetic inheritance in human males
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2023-503344-14-00 | OTHER | CTIS number EMA | None |