Ignite Creation Date:
2024-05-06 @ 6:43 PM
Last Modification Date:
2024-10-26 @ 2:53 PM
Study NCT ID:
NCT05766618
Status:
RECRUITING
Last Update Posted:
2023-03-13
First Post:
2023-02-28
Brief Title:
The Effect of Multiple Injections of PRF on The Rate of Canine Retraction
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
The Effect of Multiple Injections of Platelets Rich Fibrin i-PRF on The Rate of Canine Retraction A Split-mouth A Randomized Controlled Trial
Status:
RECRUITING
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
this clinical trial aims to prove that multiple injections will produce a steady rate of acceleration of orthodontic tooth movement
Detailed Description:
Platelet-rich fibrin injection is a second-generation platelet concentrate prepared from centrifuged blood which is a rich source of platelets stem cells and growth factors seven times greater than that released by platelet-rich plasma It is a simplified procedure with no biochemical manipulation of blood free from anticoagulants which are known to inhibit wound healing or any gelling agent and easily usable with a low rate of mistakes during the preparation procedure
A variety of growth factors are released by PRF such as platelet-derived growth factor PDGF transforming growth factor β TGF-β and vascular endothelial growth factor VEGF which play a crucial role in angiogenesis collagen synthesis and bone regeneration
Treatment with extraction especially in adult patients may take a longer time due to reported increase in bone density and lower bone regenerative rate Also the retraction process to close extraction spaces most of the time is accompanied by bone loss and root resorption as reported in the previous studies i-PRF can accelerate tooth movement in addition prevent tooth retraction undesirable side effects
A variety of growth factors are released by PRF such as platelet-derived growth factor PDGF transforming growth factor β TGF-β and vascular endothelial growth factor VEGF which play a crucial role in angiogenesis collagen synthesis and bone regeneration
Treatment with extraction especially in adult patients may take a longer time due to reported increase in bone density and lower bone regenerative rate Also the retraction process to close extraction spaces most of the time is accompanied by bone loss and root resorption as reported in the previous studies i-PRF can accelerate tooth movement in addition prevent tooth retraction undesirable side effects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None