Ignite Creation Date:
2024-05-06 @ 6:43 PM
Last Modification Date:
2024-10-26 @ 2:53 PM
Study NCT ID:
NCT05767177
Status:
RECRUITING
Last Update Posted:
2023-09-18
First Post:
2023-02-16
Brief Title:
Jejunal Ketogenesis and Type 2 Diabetes
Sponsor:
Göteborg University
Organization:
Göteborg University
Study Overview
Official Title:
Small Intestinal Ketogenesis - Potential Significance for Type 2 Diabetes in Obesity
Status:
RECRUITING
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
But2
Brief Summary:
The goal of this cross-over study in obese subjects is to learn about the common co-morbidity type 2 diabetes and the local formation of ketone bodies The type of study is an exploratory trial with the participants as own controls The main questions it aims to answer are 1 Does food intake-induced ketogenesis exist in the small intestine of obese individuals 2 Are insulin resistance the incretin GLP-1 release and the glucose transporter SGLT1 affected in obese individuals without type 2 diabetes in the same way as those with type 2 diabetes
Detailed Description:
The investigators have recently shown that the mucosa in the middle small intestine the jejunum in human volunteers produce ketones bodiesThis situation is thus contrary to the common view that ketone bodies are formed by the liver during fastingstarvation Obesity is commonly associated with hyperglycaemic conditions and diabetes mellitus type 2This has given rise to the question of whether obesity results in disturbances in the intestinal food-induced ketogenesis and whether this influence contributes to the development of type 2 diabetes mellitus
The projects questions are therefore
1 Does food intake-induced ketogenesis exist in the small intestine of obese individuals
2 Are insulin resistance the incretin GLP-1 release and the glucose transporter SGLT1 affected in obese individuals without type 2 diabetes in the same way as those with type 2 diabetes
3 If no to 2 What is the difference
The projects questions are therefore
1 Does food intake-induced ketogenesis exist in the small intestine of obese individuals
2 Are insulin resistance the incretin GLP-1 release and the glucose transporter SGLT1 affected in obese individuals without type 2 diabetes in the same way as those with type 2 diabetes
3 If no to 2 What is the difference
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None