Ignite Creation Date:
2024-05-06 @ 6:43 PM
Last Modification Date:
2024-10-26 @ 2:53 PM
Study NCT ID:
NCT05754814
Status:
RECRUITING
Last Update Posted:
2024-04-12
First Post:
2023-01-26
Brief Title:
SUper-Resolution Ultrasound Imaging of Erythrocytes SURE in Normal and Malignant Lymph Nodes
Sponsor:
Rigshospitalet Denmark
Organization:
Rigshospitalet Denmark
Study Overview
Official Title:
SUper-Resolution Ultrasound Imaging of Erythrocytes SURE in Normal and Malignant Lymph Nodes
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to visualize the small vessels in normal and cancerous lymph nodes on the neck with a new ultrasound technique
The main questions it aims to answer are
Is it possible to visualize the network of the smallest vessels in lymph nodes on the neck
Is it possible to distinguish between healthy and cancerous lymph nodes using different parameters
The participants will have 1-2 lymph nodes ultrasound scanned with a standard ultrasound technique and the new technique
The main questions it aims to answer are
Is it possible to visualize the network of the smallest vessels in lymph nodes on the neck
Is it possible to distinguish between healthy and cancerous lymph nodes using different parameters
The participants will have 1-2 lymph nodes ultrasound scanned with a standard ultrasound technique and the new technique
Detailed Description:
Super-resolution ultrasound using erythrocytes SURE is a new ultrasound technique for visualizing the very small blood vessels in the body The technique uses tracking of the bloods red blood cells erythrocytes to achieve a higher resolution of the blood vessels shape structure and blood flow The technique makes it possible to create images with much higher resolution than normal ultrasound which means that even very small blood vessels can be imaged and measured
In many diseases the small blood vessels change their function or structure One of the major disease groups where SURE has significant potential is cancer In cancerous nodes the small blood vessels change they become twisted irregular and function poorly If changes in the small vessels can be detected at an early stage using SURE it can lead to quicker diagnoses and better evaluations of the effectiveness of treatment
In this study the investigators aim to demonstrate the practical feasibility of SURE imaging in human lymph nodes and investigate the clinical relevance of SURE imaging in the diagnosis of malignant lymph nodes by comparing lymph nodes from healthy participants with lymph nodes from participants with head and neck cancer metastases or lymphoma
In many diseases the small blood vessels change their function or structure One of the major disease groups where SURE has significant potential is cancer In cancerous nodes the small blood vessels change they become twisted irregular and function poorly If changes in the small vessels can be detected at an early stage using SURE it can lead to quicker diagnoses and better evaluations of the effectiveness of treatment
In this study the investigators aim to demonstrate the practical feasibility of SURE imaging in human lymph nodes and investigate the clinical relevance of SURE imaging in the diagnosis of malignant lymph nodes by comparing lymph nodes from healthy participants with lymph nodes from participants with head and neck cancer metastases or lymphoma
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None