Ignite Creation Date:
2024-05-06 @ 6:42 PM
Last Modification Date:
2024-10-26 @ 2:53 PM
Study NCT ID:
NCT05754294
Status:
WITHDRAWN
Last Update Posted:
2023-07-24
First Post:
2023-02-22
Brief Title:
Electric Polarization of Red Blood Cells A Cohort Study to Assess the Erythrocytes Membrane Integrity Through Charge Conservation Following Cardiac Surgery
Sponsor:
Anthea Hospital Bari
Organization:
Anthea Hospital Bari
Study Overview
Official Title:
Electric Polarization of Red Blood Cells Polaris A Cohort Study to Assess the Erythrocytes Membrane Integrity Through Charge Conservation Following Conventional and Minimally Invasive Cardiac Surgery Procedures and The Related Perfusion Techniques
Status:
WITHDRAWN
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
absence of funding
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Polaris
Brief Summary:
An immediate perioperative parameter that assess the integrity of the Erythrocytes Membrane and therefore their structural quality isnt available in clinical practice and medical diagnostics except through indirect clinical biochemical tests or through the scanning electron microscope The red blood cell RBC membrane contains proteins and glycoproteins embedded in a fluid lipid bilayer that confers viscoelastic behavior Sialylated glycoproteins of the RBC membrane are responsible for a negatively charged surface which creates a repulsive electric zeta potential ΞΆ between cells These charges help prevent the interaction between RBCs and the other cells and especially between each other The zeta potential is a physical property which is exhibited by all particles in suspension The development of a net charge on any particle affects the distribution of ions in the surrounding interfacial region resulting in an increased concentration of counter ions of opposite charge to that of the particle close to the surface In this context we present a new parameter that studies the interactions of the Erythrocytes membrane treated with positive ions and their maintenance of the charge We compared the measured polarization values with the Erythrocyte Sedimentation Rate ESR expression of speed with which RBCs tend to settle inside a particular graduated capillary called Westergrens tube and Plasma Free Hemoglobin pFHb
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None