Ignite Creation Date:
2024-05-06 @ 6:41 PM
Last Modification Date:
2024-10-26 @ 2:52 PM
Study NCT ID:
NCT05751317
Status:
RECRUITING
Last Update Posted:
2023-04-19
First Post:
2023-02-20
Brief Title:
Phenotypic and Genotypic Variations of Enterococcus Spp
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Phenotypic and Genotypic Variations of Enterococcus Spp Isolated From Patients With Hospital Acquired Infections in Sohag University Hospitals Egypt
Status:
RECRUITING
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Enterococci are Gram-positive facultative anaerobic cocci arranged in short and medium chains Enterococci reside in the gastrointestinal tract and usually function commensally with humans They can however cause several infections such as urinary tract infections UTIs intra-abdominal infection bacteremia or endocarditis
Among many species identified E faecalis and E faecium are the most common species capable of causing infection and posing a threat of antimicrobial resistance with E faecalis accounting for the majority of infections
Among many species identified E faecalis and E faecium are the most common species capable of causing infection and posing a threat of antimicrobial resistance with E faecalis accounting for the majority of infections
Detailed Description:
Enterococci are Gram-positive facultative anaerobic cocci arranged in short and medium chains
Enterococci reside in the gastrointestinal tract and usually function commensally with humans They can however cause several infections such as urinary tract infections UTIs intra-abdominal infection bacteremia or endocarditis
Among many species identified E faecalis and E faecium are the most common species capable of causing infection and posing a threat of antimicrobial resistance with E faecalis accounting for the majority of infections
Pathogenic species of enterococci express many virulence factors such as adhesins gelatinase Enterococcus surface protein aggregation substances and cytolysins along with biofilm formation These factors enhance the ability of the pathogen to invade attach and survive through the acquisition of nutrients in the host tissue Their presence in drug resistant strains increases the severity of the infection
Enterococci are intrinsically resistant to antibiotics such as aminoglycosides and β-lactam-based antibiotics Moderate resistance to aminoglycosides is due to the intrinsic low permeability of the enterococcal cell wall to the large aminoglycoside molecules and is more prevalent in E faecium than E faecalis Intrinsic β-lactam resistance is due to the overexpression of penicillin-binding proteins with low affinity for β-lactams which makes E faecalis more resistant to penicillin than E faecium
Moreover enterococci can readily acquire resistance to antimicrobials and vancomycin-resistant enterococci VRE are among the priority pathogens for which new antibiotics are needed
In addition biofilm formation is one of the strategies for the enterococci to evade the hosts immune response and the inhibitory or killing effects of antibiotics
This self-produced extracellular matrix also provides a suitable microenvironment for enterococci to grow and facilitates the transmission of mobile genetic elements MGEs between bacteria Enterococcal biofilms have been implicated in indwelling device-related infections such as prosthetic valve endocarditis prosthetic joint infections and catheter-related infections
Biofilm forming bacteria show resistance to many antibiotics and immune response which results in treatment failure Given the difficulty of treating and eradicating biofilm associated infections there is an unmet need for therapeutic options other than antibiotics to prevent biofilm formation
Nanoparticles are attracting attention given their very small size and various antibacterial properties Nanoparticles can interact with bacteria per unit area which can make the antibacterial activity of nanoparticles more powerful Nanoparticles can also initiate several bactericidal pathways such as disrupting the bacterial membrane and release of intracellular components making it difficult for bacteria to become resistant
Enterococci reside in the gastrointestinal tract and usually function commensally with humans They can however cause several infections such as urinary tract infections UTIs intra-abdominal infection bacteremia or endocarditis
Among many species identified E faecalis and E faecium are the most common species capable of causing infection and posing a threat of antimicrobial resistance with E faecalis accounting for the majority of infections
Pathogenic species of enterococci express many virulence factors such as adhesins gelatinase Enterococcus surface protein aggregation substances and cytolysins along with biofilm formation These factors enhance the ability of the pathogen to invade attach and survive through the acquisition of nutrients in the host tissue Their presence in drug resistant strains increases the severity of the infection
Enterococci are intrinsically resistant to antibiotics such as aminoglycosides and β-lactam-based antibiotics Moderate resistance to aminoglycosides is due to the intrinsic low permeability of the enterococcal cell wall to the large aminoglycoside molecules and is more prevalent in E faecium than E faecalis Intrinsic β-lactam resistance is due to the overexpression of penicillin-binding proteins with low affinity for β-lactams which makes E faecalis more resistant to penicillin than E faecium
Moreover enterococci can readily acquire resistance to antimicrobials and vancomycin-resistant enterococci VRE are among the priority pathogens for which new antibiotics are needed
In addition biofilm formation is one of the strategies for the enterococci to evade the hosts immune response and the inhibitory or killing effects of antibiotics
This self-produced extracellular matrix also provides a suitable microenvironment for enterococci to grow and facilitates the transmission of mobile genetic elements MGEs between bacteria Enterococcal biofilms have been implicated in indwelling device-related infections such as prosthetic valve endocarditis prosthetic joint infections and catheter-related infections
Biofilm forming bacteria show resistance to many antibiotics and immune response which results in treatment failure Given the difficulty of treating and eradicating biofilm associated infections there is an unmet need for therapeutic options other than antibiotics to prevent biofilm formation
Nanoparticles are attracting attention given their very small size and various antibacterial properties Nanoparticles can interact with bacteria per unit area which can make the antibacterial activity of nanoparticles more powerful Nanoparticles can also initiate several bactericidal pathways such as disrupting the bacterial membrane and release of intracellular components making it difficult for bacteria to become resistant
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None