Ignite Creation Date:
2024-05-06 @ 6:41 PM
Last Modification Date:
2024-10-26 @ 2:52 PM
Study NCT ID:
NCT05742373
Status:
RECRUITING
Last Update Posted:
2024-03-07
First Post:
2023-01-27
Brief Title:
Role of Fasted Exercise on Improving Cardiometabolic Health
Sponsor:
Manchester Metropolitan University
Organization:
Manchester Metropolitan University
Study Overview
Official Title:
Investigating the Role of Fasted Exercise on Improving Cardiometabolic Health a Potential Mediatory Role of Sirtuins
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this randomised control trial is to investigate the role of fasted exercise on cardiometabolic health Participants will be assigned to one of three conditions fasted exercise fed exercise and control no exercise Participants in the exercise groups will complete four weeks of moderate intensity cycling exercise three times per week either in the fasted or fed state according to their group assignment Experimental trials involving anthropometric and cardiometabolic disease risk factor measurements as well as metabolic responses to a subsequent meal ingestion following exercise will be compared pre-intervention and post intervention
Detailed Description:
The aim of this study is to investigate the effect of fasted exercise on cardiometabolic health and the potential mediatory role of sirtuins
The objectives are to investigate
1 The effect of a single bout of fasted exercise on acute metabolic responses following a high fat meal
2 The effect of four weeks of fasted exercise training on cardiovascular and metabolic disease risk factors
3 The effect of four weeks of fasted exercise training on circulating levels and subcutaneous adipose tissue gene expression of SIRT1 SIRT3 and SIRT6
A randomised control trial will be conducted with volunteers allocated under the conditions of a no exercise control b fasted exercise training FASTEX and c fed exercise training FEDEX The pre- and post-intervention visits will consist of 50 minutes of cycling at a moderate exercise intensity for both the FASTEX and FEDEX groups The control group would not perform any exercise The FASTEX group will perform the exercise in the fasted state whilst the FEDEX and control groups will be fed a standardised breakfast meal one hour in advance of the exercise period Following the exercise period the participants will be fed a high fat meal and metabolic responses to the meal will be measured for four hours Multiple blood samples will be obtained as well as a sample of subcutaneous adipose fat tissue The FASTEX and FEDEX groups will then complete four weeks of moderate intensity continuous exercise training either fasted or fed according to their group on three days per week whilst the control group will maintain their normal sedentary lifestyle All participants will return to the laboratory for post-intervention testing at the end of the four weeks with the same protocols and measurements as the pre-intervention testing
The objectives are to investigate
1 The effect of a single bout of fasted exercise on acute metabolic responses following a high fat meal
2 The effect of four weeks of fasted exercise training on cardiovascular and metabolic disease risk factors
3 The effect of four weeks of fasted exercise training on circulating levels and subcutaneous adipose tissue gene expression of SIRT1 SIRT3 and SIRT6
A randomised control trial will be conducted with volunteers allocated under the conditions of a no exercise control b fasted exercise training FASTEX and c fed exercise training FEDEX The pre- and post-intervention visits will consist of 50 minutes of cycling at a moderate exercise intensity for both the FASTEX and FEDEX groups The control group would not perform any exercise The FASTEX group will perform the exercise in the fasted state whilst the FEDEX and control groups will be fed a standardised breakfast meal one hour in advance of the exercise period Following the exercise period the participants will be fed a high fat meal and metabolic responses to the meal will be measured for four hours Multiple blood samples will be obtained as well as a sample of subcutaneous adipose fat tissue The FASTEX and FEDEX groups will then complete four weeks of moderate intensity continuous exercise training either fasted or fed according to their group on three days per week whilst the control group will maintain their normal sedentary lifestyle All participants will return to the laboratory for post-intervention testing at the end of the four weeks with the same protocols and measurements as the pre-intervention testing
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None