Ignite Creation Date:
2024-05-06 @ 6:40 PM
Last Modification Date:
2024-10-26 @ 2:52 PM
Study NCT ID:
NCT05743660
Status:
RECRUITING
Last Update Posted:
2023-03-07
First Post:
2023-02-14
Brief Title:
Key circRNA Identification of Postoperative Delirium in Elderly Patients Undergoing Cardiac Surgery
Sponsor:
Xuzhou Central Hospital
Organization:
Xuzhou Central Hospital
Study Overview
Official Title:
Key circRNA Identification of Postoperative Delirium in Elderly Patients Undergoing Cardiac Surgery
Status:
RECRUITING
Status Verified Date:
2023-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The observational study aims to discover differentially expressed circRNAs in the peripheral blood of patients with postoperative delirium which aims to answer the main questions at
Whether there are changes in circRNA expression in peripheral blood in elderly patients with delirium after cardiopulmonary bypass surgery Whether the circRNA with altered expression plays an important role in the occurrence and development of POD What are the functions and underlying mechanisms of circRNA with altered expression in POD Voluntary patients will receive follow-up 1 day before and 7 days after surgery to assess their cognitive function and peripheral blood will be collected 1 day before and 3 days after surgery The study divided patients into POD group and non-POD group according to whether delirium occurred within 7 days after surgery
Whether there are changes in circRNA expression in peripheral blood in elderly patients with delirium after cardiopulmonary bypass surgery Whether the circRNA with altered expression plays an important role in the occurrence and development of POD What are the functions and underlying mechanisms of circRNA with altered expression in POD Voluntary patients will receive follow-up 1 day before and 7 days after surgery to assess their cognitive function and peripheral blood will be collected 1 day before and 3 days after surgery The study divided patients into POD group and non-POD group according to whether delirium occurred within 7 days after surgery
Detailed Description:
Investigators combined qRT-PCR by performing circRNAs chip analysis to study differential expression of circRNAs in plasma samples of elderly patients with non-POD who underwent cardiac surgery under general anesthesia and cardiopulmonary bypass Subsequently miRNA binding sites and associated mRNAs are predicted by bioinformatics analysis Moreover we plan to construct predicted circN-MIRNA-MRNA co-expression networks to study the main functions and pathways of target genes thereby attempting to provide a preliminary view of the potential role of a circRNA in POD The study may provide an important perspective on the differential expression of circRNA in patients with POD and may also provide insights into biomarkers and therapeutic targets of POD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None