Ignite Creation Date:
2024-05-06 @ 6:40 PM
Last Modification Date:
2024-10-26 @ 2:52 PM
Study NCT ID:
NCT05748132
Status:
COMPLETED
Last Update Posted:
2023-02-28
First Post:
2023-02-08
Brief Title:
Evaluating the Sensory Index for Success of Trigeminal RF
Sponsor:
National Cancer Institute Egypt
Organization:
National Cancer Institute Egypt
Study Overview
Official Title:
The Value of Sensory Index in Predicting the Success of Radiofrequency Treatment of Trigeminal Neuralgia A Retrospective Study
Status:
COMPLETED
Status Verified Date:
2023-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Trigeminal neuralgia TN is defined by the International Headache Society IHS as unilateral disorder characterized by brief electric shock-like pains abrupt in onset and termination and limited to the distribution of one or more divisions of the trigeminal nerve It is considered the worst type of facial pain and described as intense sharp stabbing and shooting like electric shock pain It can be triggered by touch chewing laughing shaving or face wash Interventional therapies for TN are of variable efficacy and safety and have different results for different periods of time before the recurrence of symptoms Interventional therapy for TN is either destructive with trigeminal nerve sensory function destroyed intentionally or non-destructive with decompression of the trigeminal nerve and preservation of its regular function The most common procedures in treating TN pain are the use of radiofrequency RFCombined conventional and pulsed radiofrequency CCPRF achieved comparable pain relief to PRF treatment alone in patients with chronic pain the combination of PRF and CRF would increase the effect of CRF and reduce the need for long-duration CRF LCRF and its attendant side effects
Detailed Description:
Trigeminal neuralgia TN is defined by the International Headache Society IHS as unilateral disorder characterized by brief electric shock-like pains abrupt in onset and termination and limited to the distribution of one or more divisions of the trigeminal nerve It is considered the worst type of facial pain and described as intense sharp stabbing and shooting like electric shock pain It can be triggered by touch chewing laughing shaving or face wash
The IHS suggests a classification of TN as either classic essential or idiopathic TN CTN or symptomatic TN STN pain indistinguishable from that of CTN but caused by a demonstrable structural lesion other than vascular compression
Treatment of TN is conservative surgical or interventional Pharmacotherapy with carbamazepine is tried early in cases of TN but has many side effects Other medications can be used in the treatment of TN include oxycarbazepine gabapentin pregabalin baclofen valproate clonazepam phenytoin and lamotrigime
The most clinically appropriate treatment includes surgical microvascular decompression MVD stereotactic radiation therapy gamma knife SGK percutaneous balloon decompression percutaneous glycerol rhizolysis percutaneous radiofrequency RF of the Gasserian ganglion GG and GG stimulation and neuromodulation
Interventional therapies for TN are of variable efficacy and safety and have different results for different periods of time before the recurrence of symptoms Interventional therapy for TN is either destructive with trigeminal nerve sensory function destroyed intentionally or non-destructive with decompression of the trigeminalnerve and preservation of its regular function The most common procedures in treating TN pain are the use of radiofrequency RF
Radiofrequency thermos-coagulation of the GG is thought to selectively destroy the pain fibers by thermos-coagulation at 65C that helps reduce pain and prevent triggering but can cause bothersome dysesthesia
Another method pulsed radiofrequency PRF which defined as the delivery of short pulses of RF via a needle tip thereby a short exposure at the same temperature will result in less thermal tissue destruction
Combined conventional and pulsed radiofrequency CCPRF achieved comparable pain relief to PRF treatment alone in patients with chronic pain the combination of PRF and CRF would increase the effect of CRF and reduce the need for long-duration CRF LCRF and its attendant side effects
The IHS suggests a classification of TN as either classic essential or idiopathic TN CTN or symptomatic TN STN pain indistinguishable from that of CTN but caused by a demonstrable structural lesion other than vascular compression
Treatment of TN is conservative surgical or interventional Pharmacotherapy with carbamazepine is tried early in cases of TN but has many side effects Other medications can be used in the treatment of TN include oxycarbazepine gabapentin pregabalin baclofen valproate clonazepam phenytoin and lamotrigime
The most clinically appropriate treatment includes surgical microvascular decompression MVD stereotactic radiation therapy gamma knife SGK percutaneous balloon decompression percutaneous glycerol rhizolysis percutaneous radiofrequency RF of the Gasserian ganglion GG and GG stimulation and neuromodulation
Interventional therapies for TN are of variable efficacy and safety and have different results for different periods of time before the recurrence of symptoms Interventional therapy for TN is either destructive with trigeminal nerve sensory function destroyed intentionally or non-destructive with decompression of the trigeminalnerve and preservation of its regular function The most common procedures in treating TN pain are the use of radiofrequency RF
Radiofrequency thermos-coagulation of the GG is thought to selectively destroy the pain fibers by thermos-coagulation at 65C that helps reduce pain and prevent triggering but can cause bothersome dysesthesia
Another method pulsed radiofrequency PRF which defined as the delivery of short pulses of RF via a needle tip thereby a short exposure at the same temperature will result in less thermal tissue destruction
Combined conventional and pulsed radiofrequency CCPRF achieved comparable pain relief to PRF treatment alone in patients with chronic pain the combination of PRF and CRF would increase the effect of CRF and reduce the need for long-duration CRF LCRF and its attendant side effects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None