Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006513
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-11-20
Brief Title:
Assessing the Occupation Burden in COPD
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2006-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To assess the population burden of occupational exposures in the prevalence and progression of chronic obstructive pulmonary disease COPD
Detailed Description:
BACKGROUND
Chronic obstructive pulmonary disease is the only one of the top four or five leading causes of death in the US with worsening epidemiological trends Cigarette smoking accounts for approximately 85 percent-90 percent of cases but the other 10 percent-15 percent of the attributable risk still represents a substantial fraction of this disease that remains unexplained Recently several studies in various countries have addressed whether certain occupational exposures primarily those relating to dusts vapors gases andor fumes are potential risk factors for COPD Most of these studies have shown elevated odds ratios or relative risks although not always to a statistically significant level
DESIGN NARRATIVE
A population sample of the continental United States of those aged 55-75 supplemented by an enriched sample in geographic hot spots identified by the National Institute for Occupational Safety and Health NIOSH through respiratory diseases mapping Structured telephone interviews assessed demographics health status smoking exposures and occupational histories High risk jobs were coded using a job matrix system independent of subject report of specific exposures Two hundred thirty-four of those with COPD with over-sampling of those with greater severity were followed at 12-14 months to assess health status and health services utilization as well as decrements in quality of life
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Chronic obstructive pulmonary disease is the only one of the top four or five leading causes of death in the US with worsening epidemiological trends Cigarette smoking accounts for approximately 85 percent-90 percent of cases but the other 10 percent-15 percent of the attributable risk still represents a substantial fraction of this disease that remains unexplained Recently several studies in various countries have addressed whether certain occupational exposures primarily those relating to dusts vapors gases andor fumes are potential risk factors for COPD Most of these studies have shown elevated odds ratios or relative risks although not always to a statistically significant level
DESIGN NARRATIVE
A population sample of the continental United States of those aged 55-75 supplemented by an enriched sample in geographic hot spots identified by the National Institute for Occupational Safety and Health NIOSH through respiratory diseases mapping Structured telephone interviews assessed demographics health status smoking exposures and occupational histories High risk jobs were coded using a job matrix system independent of subject report of specific exposures Two hundred thirty-four of those with COPD with over-sampling of those with greater severity were followed at 12-14 months to assess health status and health services utilization as well as decrements in quality of life
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL067438 | NIH | None | httpsreporternihgovquickSearchR01HL067438 |