Ignite Creation Date:
2024-05-06 @ 6:40 PM
Last Modification Date:
2024-10-26 @ 2:52 PM
Study NCT ID:
NCT05741853
Status:
RECRUITING
Last Update Posted:
2023-07-03
First Post:
2023-02-03
Brief Title:
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
Sponsor:
University of Texas at Austin
Organization:
University of Texas at Austin
Study Overview
Official Title:
Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia
Status:
RECRUITING
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia PPA While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language monolinguals there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA This stage 2 efficacy clinical trial seeks to establish the effects of culturally and linguistically tailored speech-language interventions administered to bilingual individuals with PPA
The overall aim of the intervention component of this study is to establish the relationships between the bilingual experience eg how often each language is used how strong each language is and treatment response of bilinguals with PPA Specifically the investigators will evaluate the benefits of tailored speech-language intervention administered in both languages to bilingual individuals with PPA 60 individuals will be recruited The investigators will conduct an assessment before treatment after treatment and at two follow-ups 6 and 12-months post-treatment in both languages When possible a structural scan of the brain magnetic resonance image will be collected before treatment in order to identify if brain regions implicated in bilingualism are associated with response to treatment In addition to the intervention described herein 30 bilingual individuals with PPA will be recruited to complete behavioral cognitive-linguistic testing and will not receive intervention Results will provide important knowledge about the neural mechanisms of language re-learning and will address how specific characteristics of bilingualism influence cognitive reserve and linguistic resilience in PPA
The overall aim of the intervention component of this study is to establish the relationships between the bilingual experience eg how often each language is used how strong each language is and treatment response of bilinguals with PPA Specifically the investigators will evaluate the benefits of tailored speech-language intervention administered in both languages to bilingual individuals with PPA 60 individuals will be recruited The investigators will conduct an assessment before treatment after treatment and at two follow-ups 6 and 12-months post-treatment in both languages When possible a structural scan of the brain magnetic resonance image will be collected before treatment in order to identify if brain regions implicated in bilingualism are associated with response to treatment In addition to the intervention described herein 30 bilingual individuals with PPA will be recruited to complete behavioral cognitive-linguistic testing and will not receive intervention Results will provide important knowledge about the neural mechanisms of language re-learning and will address how specific characteristics of bilingualism influence cognitive reserve and linguistic resilience in PPA
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None