Ignite Creation Date:
2024-05-06 @ 6:39 PM
Last Modification Date:
2024-10-26 @ 2:52 PM
Study NCT ID:
NCT05739084
Status:
RECRUITING
Last Update Posted:
2023-02-22
First Post:
2023-01-26
Brief Title:
Gene Signatures Searching of SensitivityResistance to Neoadjuvant Radiotherapy in Patients With Resectable STS
Sponsor:
Centre Leon Berard
Organization:
Centre Leon Berard
Study Overview
Official Title:
RADIOSARC Searching for Specific Gene Signatures of SensitivityResistance to Neoadjuvant Radiotherapy in Adults Patients With Resectable Soft Tissue Sarcomas of Limbs
Status:
RECRUITING
Status Verified Date:
2023-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RADIOSARC
Brief Summary:
To date the radiation oncologist are missing biomarkers predictive of responseresistance to RT in order to identify patients who may benefit from RT and personalize the RT schedule Our proposal is to conduct a cohort study aiming at identifying transcriptomic biomarkers predictive of sensitivity andor resistance to RT in limbs STS patients
Detailed Description:
Whether RT should be performed pre or post-operatively is still a debated question To date the radiation oncologist are missing signature of responseresistance to RT in order to identify patients who may benefit from RT and personalize the RT schedule Therefore predicting the likelihood of responseresistance to RT is essential The individual exploration with high-throughput approaches will participate in describing biological mechanisms involved in STS tumor cell pan-resistance thus identifying potential molecular targets that could be inhibited to reverse intrinsic radioresistance In this context our proposal is to conduct a cohort study aiming at identifying transcriptomic signature predictive of sensitivity andor resistance to RT in limbs STS patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| GDPR registration Number | OTHER | R201-004-171 | None |