Ignite Creation Date:
2024-05-06 @ 6:37 PM
Last Modification Date:
2024-10-26 @ 2:51 PM
Study NCT ID:
NCT05723315
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-02-10
First Post:
2023-02-01
Brief Title:
Effect of rhBNP on CMD in Patients With STEMI After PPCI
Sponsor:
Henan Institute of Cardiovascular Epidemiology
Organization:
Henan Institute of Cardiovascular Epidemiology
Study Overview
Official Title:
Effect of rhBNP on Coronary Microcirculation in Patients With Acute ST-segment Elevation Myocardial Infarction After Primary PCI
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The target population of this interventional study was STEMI patients Primary discussion Early rhBNP reduces microcirculation obstruction in STEMI patients undergoing primary PCI
Detailed Description:
Direct percutaneous coronary intervention is the preferred reperfusion strategy for acute ST-segment elevation myocardial infarction During the opening of infarct-related vessels 5-50 of patients showed slow flow or no reflow and other coronary microcirculation dysfunction which aggravated myocardial injury and increased the incidence and mortality of heart failure Studies have shown that recombinant human brain natriuretic peptide rhBNP can reduce reperfusion injury and reduce myocardial infarction area CMD Prolonged ischemia leads to rapid depletion of intracellular ATP and tissue metabolic acidosis Blood flow irrigation during reperfusion leads to decreased levels of ATP precursors calcium overload in mitochondria release of a large number of inflammatory factors and oxygen free radicals which can lead to injury or death of myocardial and endothelial cells rhBNP can enhance the activity of antioxidant enzymes reduce the irreversible oxidative damage caused by free radicals to myocardium reduce the myocardial infarction area during ischemia reperfusion and may reduce the reperfusion injury and protect the viable myocardium
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None