Ignite Creation Date:
2024-05-06 @ 6:37 PM
Last Modification Date:
2024-10-26 @ 2:51 PM
Study NCT ID:
NCT05726604
Status:
RECRUITING
Last Update Posted:
2023-06-09
First Post:
2023-02-03
Brief Title:
4D CT Scan Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy
Sponsor:
Central Hospital Saint Quentin
Organization:
Central Hospital Saint Quentin
Study Overview
Official Title:
4D CT Scan With Respiratory Gating Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy
Status:
RECRUITING
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RD3D4
Brief Summary:
To establish if the cardiac radiation dose assesment is well aproximated with routine 3D CT scan compared to 4D CT experimental scan with respiratory gating breath motion monitoring The study population relates to left side breast cancers female patients that require a radiation therapy treatment
Detailed Description:
As a standard of care the postoperative breast cancers radiation therapy is generally based on a 3 dimensions CT scan that does not incorporate the breathing motion by definition
Meanwhile the patients must commonly receive the treatment in free motion breathing condition
More of that the Cardiac dose especially the LAD left anterior descending artery dose has been established as the main cause of radiation induced ischemic heart disease RIHD and should be consider in the first place
In more concrete terms the higher the LAD dose is the greater the RIHD relates arise the LAD dose by 1 Gy means a 74 higher risk to cause a RIHD during the next 5 years
That being said to determine if the cardiac dosimetry and the dose-volume histograms specifically for the left side breast cancer treatments including or not the internal mammary artery obtained from a 3D CT scan reflect well or not the reality which is widely subject to the breathing motion
Finally because it has been established that a 4D CT scan can monitor the breathing motion it seems definitely interesting to compare it with the average 3D CT scan to address this concern
Meanwhile the patients must commonly receive the treatment in free motion breathing condition
More of that the Cardiac dose especially the LAD left anterior descending artery dose has been established as the main cause of radiation induced ischemic heart disease RIHD and should be consider in the first place
In more concrete terms the higher the LAD dose is the greater the RIHD relates arise the LAD dose by 1 Gy means a 74 higher risk to cause a RIHD during the next 5 years
That being said to determine if the cardiac dosimetry and the dose-volume histograms specifically for the left side breast cancer treatments including or not the internal mammary artery obtained from a 3D CT scan reflect well or not the reality which is widely subject to the breathing motion
Finally because it has been established that a 4D CT scan can monitor the breathing motion it seems definitely interesting to compare it with the average 3D CT scan to address this concern
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None