Ignite Creation Date:
2024-05-06 @ 6:37 PM
Last Modification Date:
2024-10-26 @ 2:51 PM
Study NCT ID:
NCT05729009
Status:
RECRUITING
Last Update Posted:
2024-03-26
First Post:
2023-02-06
Brief Title:
The Evolution of Systemic Microvascular Reactivity in Heart Transplant Patients
Sponsor:
National Institute of Cardiology Laranjeiras Brazil
Organization:
National Institute of Cardiology Laranjeiras Brazil
Study Overview
Official Title:
The Evolution of Systemic Microvascular Reactivity in Heart Transplant Patients
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The evolution of systemic microvascular reactivity may aid in the comprehension of cardiovascular physiology in heart transplantation patients and possibly suggest the non-invasive evaluation of skin microcirculation as an ancillary tool in the clinical evaluation of these patients
Detailed Description:
Introduction Systemic microvascular reactivity MR is an essential component of cardiovascular physiology being studied through non-invasive techniques in readily accessible body regions such as the skin surface Heart transplant HT is a treatment considered to selected patients with advanced heart failure The main cause of long-term mortality after HT is graft vascular disease GVD a condition which starts with endothelial dysfunction To know the evolution of systemic MR in patients subjected to HT can help to find prognostic factors Objective The present study aims to perform the prospective evaluation of systemic MR in adult patients before and two years after HT at a quaternary hospital correlating the findings with clinical variables Methods Systemic MR will be evaluated in the skin of the forearm using laser speckle contrast imaging with acetylcholine ACh iontophoresis followed by postocclusive reactive hyperemia PORH before and after HT Measurements will be correlated to patient clinical profile hemodynamic and echocardiographic data Expected results The evolution of systemic MR may aid in the comprehension of cardiovascular physiology in HT patients and possibly suggest the non-invasive evaluation of skin microcirculation as an ancillary tool in the clinical evaluation of these patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None