Ignite Creation Date:
2024-05-06 @ 6:37 PM
Last Modification Date:
2024-10-26 @ 2:51 PM
Study NCT ID:
NCT05729880
Status:
COMPLETED
Last Update Posted:
2024-05-09
First Post:
2023-01-16
Brief Title:
Can Ultrasound be Used as a Measure of Muscle Quality A Validation Study Comparing Ultrasound With MRI and MRS in Older and Younger Persons
Sponsor:
University of Exeter
Organization:
University of Exeter
Study Overview
Official Title:
Can Ultrasound be Used as a Measure of Muscle Quality A Validation Study Comparing Ultrasound With MRI and MRS in Older and Younger Persons
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to see if ultrasound can be used as a reliable and valid method to measure fatty infiltration muscle thickness and muscle architecture to provide a quick cheap and mobile alternative measure of muscle quality to MRI
The MRS and MRI images will be used to validate the ultrasound images
The MRS and MRI images will be used to validate the ultrasound images
Detailed Description:
A key hallmark of the natural biology of ageing is a progressive loss of skeletal muscle mass strength and aerobic capacity termed sarcopenia Cruz-Jentoft et al 2019a The association between muscle loss mass and quality and increased incidence of falls fractures metabolic disease and other health complications is well established Despite exercise and physiotherapy recovery from these is often incomplete and studies have failed to identify fully effective countermeasures Reeves et al 2005 Ways to objectively measure the clinical effectiveness of the countermeasures are also limited
Muscle quality can be measured in terms of muscle thickness architecture pennation angle and fascicle length and fatty infiltration At present ultrasound muscle thickness and architecture have been shown against MRI to be a reliable and valid but fatty infiltration can only be measured reliably using MRI MRI is an expensive time consuming and immobile technique limiting its use as a clinical tool in a rehabilitative setting Finding a cheaper quicker and mobile alternative such as ultrasound would enable clinicians to gather useful information on patient muscle quality in an objective manner and use this information to tailor treatment accordingly
15 old 50y and 15 young 40y will be recruited MRI MRS and Ultrasound will be measured in each participant in calf and thigh muscle at the same location within a 1 hour time frame
MRI and MRS will provide the validation to ultrasound fatty infiltration
Muscle quality can be measured in terms of muscle thickness architecture pennation angle and fascicle length and fatty infiltration At present ultrasound muscle thickness and architecture have been shown against MRI to be a reliable and valid but fatty infiltration can only be measured reliably using MRI MRI is an expensive time consuming and immobile technique limiting its use as a clinical tool in a rehabilitative setting Finding a cheaper quicker and mobile alternative such as ultrasound would enable clinicians to gather useful information on patient muscle quality in an objective manner and use this information to tailor treatment accordingly
15 old 50y and 15 young 40y will be recruited MRI MRS and Ultrasound will be measured in each participant in calf and thigh muscle at the same location within a 1 hour time frame
MRI and MRS will provide the validation to ultrasound fatty infiltration
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None