Ignite Creation Date:
2024-05-06 @ 6:37 PM
Last Modification Date:
2024-10-26 @ 2:51 PM
Study NCT ID:
NCT05725837
Status:
RECRUITING
Last Update Posted:
2024-05-08
First Post:
2023-02-02
Brief Title:
Effects of Paroxetine on Cardiovascular Function in Septic Patients
Sponsor:
Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Organization:
Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Study Overview
Official Title:
Effects of Paroxetine on Cardiovascular Function in Septic Patients a Randomized Placebo Controlled Trial
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
It is known that septic shock is characterized by arterial hypotension decreased peripheral vascular resistance and hyporeactivity to vasoconstrictor agents with NO being an important mediator of this organ dysfunction Data in the literature have shown that hyporeactivity to catecholamines is associated with a decrease in the density of α and ß receptors in the aorta and heart respectively as well as an increase in GRK2 levels and that NO contributes to the increase of this kinase in sepsis
Based on this it is hypothesized that cardiac dysfunction and decreased peripheral vascular resistance observed in sepsis may result from an increase in GRK2 activity andor expression and its inhibition may be a relevant therapeutic target in septic shock patients Based on this line a measurable clinical benefit of paroxetine through the regulation of GRK2 expression in patients with septic shock is postulated
Based on this it is hypothesized that cardiac dysfunction and decreased peripheral vascular resistance observed in sepsis may result from an increase in GRK2 activity andor expression and its inhibition may be a relevant therapeutic target in septic shock patients Based on this line a measurable clinical benefit of paroxetine through the regulation of GRK2 expression in patients with septic shock is postulated
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None