Ignite Creation Date:
2024-05-06 @ 6:37 PM
Last Modification Date:
2024-10-26 @ 2:51 PM
Study NCT ID:
NCT05729906
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-11-30
First Post:
2023-01-20
Brief Title:
Dynamic Predictions of the Links Between Psychological and Physical Health of Older Patients in Nursing Home
Sponsor:
University Hospital Tours
Organization:
University Hospital Tours
Study Overview
Official Title:
Dynamic Predictions of the Links Between Psychological and Physical Health of Older Patients in Nursing Home Via the Integration of Multi-omics Data
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BioMIND
Brief Summary:
Taking the older person as a whole is now essential to age well and prevent loss of functional independence However the relationship between physical and mental health remains not well understood Combining the exploration of markers of inflammation endocrine nutritional and metabolic functions along with long-term monitoring of older persons could allow for a comprehensive understanding of the biological phenotype regardless of underlying pathologies The primary objective will be to simultaneously test the psychosomatic model and the disability model in order to more fully account for the dynamic causal relationships between physical and mental health in older people The investigators will investigate the mediating role of the biological phenotype on these relationships between mental and physical health The independent and then combined analysis of specific candidate biomarkers will open up the possibility of identifying a biological mediation between mental and physical health Furthermore this will also allow us to deepen our understanding of the evolution of the immune-endocrine-metabolic state and more broadly of the biological phenotype of older people during aging
Detailed Description:
Promoting the health of older people to better support them remains one of the major challenges of the 21st century More and more experts in gerontology doctors psychologists sociologists are now advocating a holistic approach to older people The recent recommendations of the WHO 2016 also invite us to favor an approach to aging centered on the potentialities and resources of older people more than on their deficiencies and diseases Thus taking into account the older person in his or her entirety body and mind is a must for aging well and preventing the loss of functional independence However the relationship between physical and mental health remains poorly understood
The psychosomatic model postulates that well-being and positive affects have an impact on physical health It has thus been shown that good psychological health eg positive mood hope optimism has long-term beneficial effects on longevity cardiovascular health and chronic diseases Conversely poor mental health eg presence of depressive symptoms affects the health of older subjects and increases mortality risk These results are in line with the so-called top-down approaches which postulate that well-being is a psychological trait that is the cause of future personal evaluations In this psychosomatic approach well-being positive affect ie good psychological health is seen as antecedent to physical health Naturally it would seem unlikely that well-being would predict improved health for older people However well-being or the presence of positive affect could well predict different trajectories of health in ill older people
In contrast the so-called disability model postulates that physical health problems have an impact on psychological health including well-being This bottom-up approach considers physical health problems as antecedents of well-being A study conducted by members of the laboratory supporting this project argues for this approach The results show that poor physical health would unidirectionally predict poor life satisfaction over the long termHowever no study to date has been able to confirm the prevalence of one model over the other
The main hypothesis of this research is based on the presence of a bi-directional pattern between physical and psychological health and thus on the absence of a unique prevalence of one pattern over the other for the entire target elderly population The investigators also hypothesize that the causal links between physical and psychological health may vary over time as a function of specific mediators including inflammatory and metabolomic profiles Our second hypothesis thus postulates that biological profiles could mediate the bi-directional links between physical and psychological health For example the investigators know that negative psychological affects have a negative impact on our physical health so the investigators can assume that positive psychological affects can produce an anti-inflammatory effect thus allowing us to be in better physical health protective factor
The psychosomatic model postulates that well-being and positive affects have an impact on physical health It has thus been shown that good psychological health eg positive mood hope optimism has long-term beneficial effects on longevity cardiovascular health and chronic diseases Conversely poor mental health eg presence of depressive symptoms affects the health of older subjects and increases mortality risk These results are in line with the so-called top-down approaches which postulate that well-being is a psychological trait that is the cause of future personal evaluations In this psychosomatic approach well-being positive affect ie good psychological health is seen as antecedent to physical health Naturally it would seem unlikely that well-being would predict improved health for older people However well-being or the presence of positive affect could well predict different trajectories of health in ill older people
In contrast the so-called disability model postulates that physical health problems have an impact on psychological health including well-being This bottom-up approach considers physical health problems as antecedents of well-being A study conducted by members of the laboratory supporting this project argues for this approach The results show that poor physical health would unidirectionally predict poor life satisfaction over the long termHowever no study to date has been able to confirm the prevalence of one model over the other
The main hypothesis of this research is based on the presence of a bi-directional pattern between physical and psychological health and thus on the absence of a unique prevalence of one pattern over the other for the entire target elderly population The investigators also hypothesize that the causal links between physical and psychological health may vary over time as a function of specific mediators including inflammatory and metabolomic profiles Our second hypothesis thus postulates that biological profiles could mediate the bi-directional links between physical and psychological health For example the investigators know that negative psychological affects have a negative impact on our physical health so the investigators can assume that positive psychological affects can produce an anti-inflammatory effect thus allowing us to be in better physical health protective factor
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None