Ignite Creation Date:
2024-05-06 @ 6:35 PM
Last Modification Date:
2024-10-26 @ 2:51 PM
Study NCT ID:
NCT05714722
Status:
COMPLETED
Last Update Posted:
2024-02-12
First Post:
2023-01-27
Brief Title:
Epiction of the Genomic and Genetic Landscape Identifies CCL5 as a Protective Factor in Colorectal Neuroendocrine Carcinoma
Sponsor:
Zhejiang University
Organization:
Zhejiang University
Study Overview
Official Title:
Epiction of the Genomic and Genetic Landscape Identifies CCL5 as a Protective Factor in Colorectal Neuroendocrine Carcinoma
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background Colorectal neuroendocrine carcinomas CRNECs are highly aggressive tumours with poor prognosis and low incidence To date the genomic landscape and molecular pathway alterations have not been elucidated
Methods Tissue sections and clinical information were collected as an in-house cohort 2010-2020 Large-scale genomic and genetic panels were applied to identify the genomic and genetic alterations of CRNEC Through the depiction of the genomic landscape and transcriptome profile we compared the difference between CRNEC and CR neuroendocrine tumours CRNETs Immunohistochemistry IHC staining and immunofluorescence IF staining were performed to confirm the genetic alterations
Methods Tissue sections and clinical information were collected as an in-house cohort 2010-2020 Large-scale genomic and genetic panels were applied to identify the genomic and genetic alterations of CRNEC Through the depiction of the genomic landscape and transcriptome profile we compared the difference between CRNEC and CR neuroendocrine tumours CRNETs Immunohistochemistry IHC staining and immunofluorescence IF staining were performed to confirm the genetic alterations
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None