Ignite Creation Date:
2024-05-06 @ 6:35 PM
Last Modification Date:
2024-10-26 @ 2:51 PM
Study NCT ID:
NCT05719740
Status:
RECRUITING
Last Update Posted:
2023-02-09
First Post:
2023-01-31
Brief Title:
Osteocrin and Vascular Complications
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Osteocrin a Novel Predictive Bone-derived Humoral Factorin Diabetes Mellitus and Its Relation With Glycemic Control and Vascular Complications
Status:
RECRUITING
Status Verified Date:
2023-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Osteocrin
Brief Summary:
In this study we aimed to describe the role of bone-derived factor osteocrin in glucose metabolism micro and macrovascular complications in diabetic patients Thus further investigations of the endocrine system through bone-derived hormones may provide as new perspectives on the prediction prevention and treatment of diabetes mellitus
Detailed Description:
Diabetes mellitus DM remained the most common metabolic disorder worldwide occupying the 8th leading cause of death1 Defining new predictive biomarkers in diabetes would provide a window of opportunity for preventive andor therapeutic interventions to prevent or delay the onset of irreversible long-term micro and or macro vascular complications Progressive micro vascular vaso-degeneration is the major factor in progression of diabetic complications and contribute greatly to the increased mortality and morbidity 2 Where Hemodynamic-mediated vascular injury was considered as one mechanism in the pathogenesis of diabetic nephropathy 3 Bone disorders have been drawing attention as a novel diabetic complication and diabetes is associated with an increased risk of osteoporotic fracture 4-6 Bone is considered as an endocrine organ that influences various organs and tissues via the secretion of multiple bone derived hormones 7-8 These endocrinal functions are for example glucose homeostasis 9 appetite control 10 fat deposition 11 skeletal muscle adaptation 12 male fertility 13 and cognition 14
Therefore these bone-derived hormones can become useful biomarkers for predicting the incidence of diabetes and the progression of diabetic complications Osteocrin OSTN a bone-derived humoral factor is a small secreted peptide cloned from bone and muscle complementary DNA cDNA libraries 15 Osteocrin Ostn is secreted protein produced by cells of the osteoblast lineage that shows a well conserved homology with members of the natriuretic peptide NP family with prohormone-like characteristics 17 To date the exact role of Ostn has not been elucidated
In this study we aimed to describe the role of bone-derived factor osteocrin in glucose metabolism micro and macrovascular complications in diabetic patients Thus further investigations of the endocrine system through bone-derived hormones may provide as new perspectives on the prediction prevention and treatment of diabetes mellitus
Therefore these bone-derived hormones can become useful biomarkers for predicting the incidence of diabetes and the progression of diabetic complications Osteocrin OSTN a bone-derived humoral factor is a small secreted peptide cloned from bone and muscle complementary DNA cDNA libraries 15 Osteocrin Ostn is secreted protein produced by cells of the osteoblast lineage that shows a well conserved homology with members of the natriuretic peptide NP family with prohormone-like characteristics 17 To date the exact role of Ostn has not been elucidated
In this study we aimed to describe the role of bone-derived factor osteocrin in glucose metabolism micro and macrovascular complications in diabetic patients Thus further investigations of the endocrine system through bone-derived hormones may provide as new perspectives on the prediction prevention and treatment of diabetes mellitus
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None