Ignite Creation Date:
2024-05-06 @ 6:34 PM
Last Modification Date:
2024-10-26 @ 2:50 PM
Study NCT ID:
NCT05711836
Status:
COMPLETED
Last Update Posted:
2023-02-08
First Post:
2023-02-01
Brief Title:
Role of HLA Genes and Innate Immunity in the Phenotypic Variability of COVID-19
Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Organization:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study Overview
Official Title:
Role of HLA Genes and Innate Immunity in the Phenotypic Variability of COVID-19 an Italian Prospective Multicenter Association Study
Status:
COMPLETED
Status Verified Date:
2023-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
3490
Brief Summary:
Case-control prospective retrospective association study of patients infected with SARS-CoV2 and cured by COVID19 Recruited patients were divided into two cohorts cases patients with respiratory failure that required hospitalization and ventilatory assistance Controls patients who had oligo-asymptomatic forms of COVID19 Patients blood samples were collected on bibula paper from which genomic DNA was extracted Next-generation sequencing of HLA and innate immunity genes was performed on these samples Genetic risk and protective variants were identified based on the distribution of allele frequencies in the two cohorts The aim of the study is to evaluate the role of genes of the HLA system and innate immunity in modulating the host response to SARS-CoV2 infection The identification of these factors is essential from the perspective of public health identifying individuals most in need of protection from infection as they are at higher risk of severe forms basic research characterization of molecular mechanisms of disease and therapeutics through knowledge of basic mechanisms identify potential therapeutic targets and optimize the protective efficacy of vaccines
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None