Ignite Creation Date:
2024-05-06 @ 6:32 PM
Last Modification Date:
2024-10-26 @ 2:50 PM
Study NCT ID:
NCT05699902
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-01-26
First Post:
2022-12-11
Brief Title:
Pectoral Nerve Block During Mastectomy
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
The Effect of Pectoral Nerve Block as a Part of Enhanced Recovery After Mastectomy
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PNB
Brief Summary:
Impact of pectoral nerve block on postoperative pain and quality of recovery in patients undergoing breast cancer surgery A prospective study
Detailed Description:
Breast cancer is the most common malignancy in women surgery is still the mainstay for the treatment of breast cancer
Postoperative pain can seriously reduce the quality of patients life and acute pain can even trigger chronic pain syndrome Thoracic paravertebral thoracic epidural intercostal nerve and interscalene brachial plexus blocks have been used for anesthesia and abirritation during mastectomy but their applications are limited by the complicated technique of the procedures and several complications
In recent years there has been increasing interest on a novel less invasive technique the pectoral nerve PECS block Numerous clinical trials have focused on the analgesic potential of the pectoral nerve block in breast augmentation surgery small breast surgery and breast cancer surgery and have shown positive results
Several prospective observational studies in recent years demonstrated that postoperative pain following breast surgery becomes chronic in up to 57 of women
One of the most important risk factors is insufficiently treated postoperative acute pain The current gold standard for acute postoperative pain is a preventive procedure-specific multimodal treatment including nonopioids opioids and regional analgesia
A recently published Cochrans meta-analysis demonstrated that regional analgesia eg paravertebral block PVB local infiltration might even reduce the risk of chronic postsurgical pain after breast surgery According to a recently published guidelines pectoral nerves PECS blocks seem to be an effective alternative to PVB to manage effectively postsurgical pain in major breast surgeryAnatomical studies revealed a different local anaesthetic spread following injections between the pectoralis major and minor muscles PECS I and a combination of the latter injection with a deeper injection between the pectoralis minor and serratus anterior muscles PECS II but the results were not conclusive Many trials have been published and some meta-analyses revealed a high analgesic efficacy following PECS II blocks compared with no block or PVB
However one of these meta-analyses was criticised because of methodological problems eg evidence assessment missing sham block group pain intensities not analysed separately for resting pain and pain during movement and comparisons with other established or emerging regional anaesthetic techniques eg local infiltration erector spinae block were not performed
Postoperative pain can seriously reduce the quality of patients life and acute pain can even trigger chronic pain syndrome Thoracic paravertebral thoracic epidural intercostal nerve and interscalene brachial plexus blocks have been used for anesthesia and abirritation during mastectomy but their applications are limited by the complicated technique of the procedures and several complications
In recent years there has been increasing interest on a novel less invasive technique the pectoral nerve PECS block Numerous clinical trials have focused on the analgesic potential of the pectoral nerve block in breast augmentation surgery small breast surgery and breast cancer surgery and have shown positive results
Several prospective observational studies in recent years demonstrated that postoperative pain following breast surgery becomes chronic in up to 57 of women
One of the most important risk factors is insufficiently treated postoperative acute pain The current gold standard for acute postoperative pain is a preventive procedure-specific multimodal treatment including nonopioids opioids and regional analgesia
A recently published Cochrans meta-analysis demonstrated that regional analgesia eg paravertebral block PVB local infiltration might even reduce the risk of chronic postsurgical pain after breast surgery According to a recently published guidelines pectoral nerves PECS blocks seem to be an effective alternative to PVB to manage effectively postsurgical pain in major breast surgeryAnatomical studies revealed a different local anaesthetic spread following injections between the pectoralis major and minor muscles PECS I and a combination of the latter injection with a deeper injection between the pectoralis minor and serratus anterior muscles PECS II but the results were not conclusive Many trials have been published and some meta-analyses revealed a high analgesic efficacy following PECS II blocks compared with no block or PVB
However one of these meta-analyses was criticised because of methodological problems eg evidence assessment missing sham block group pain intensities not analysed separately for resting pain and pain during movement and comparisons with other established or emerging regional anaesthetic techniques eg local infiltration erector spinae block were not performed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None