Ignite Creation Date:
2024-05-06 @ 6:32 PM
Last Modification Date:
2024-10-26 @ 2:49 PM
Study NCT ID:
NCT05692752
Status:
COMPLETED
Last Update Posted:
2023-01-20
First Post:
2022-12-22
Brief Title:
Expression of microRNA-133a and microRNA-208b in Acute Myocardial Infarction
Sponsor:
Islamia University of Bahawalpur
Organization:
Islamia University of Bahawalpur
Study Overview
Official Title:
Expression of microRNA-133a and microRNA-208b in Acute Myocardial Infarction Egyptian Patients
Status:
COMPLETED
Status Verified Date:
2023-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Cardiac-enriched micro-RNAs miRNAs micro RNA 208b and 133aMiR-208b MiR-133a corresponds to the health and disorders of the cardiovascular system An intron of the cardiac myosin heavy chain gene MYH7 encodes miR-208b It is found on chromosome 14 in humans Identify new diagnostic biomarkers based on miRNAs researchers examine the expression of miR-133a and 208b at various time points 04 hours 08 hours 12 hours 24 hours 48 hours following the development of the infarct and compared it to the traditional myocardial infarction biomarkers cardiac troponine cTnl and Creatine kinase-MB CK-MB
Detailed Description:
The 98 of human genes are non-coding RNA which is further divided into long non-coding RNA lncRNA 200 bp and short non-coding RNA 200 bp including microRNA miRNA and circular RNA More than 2000 human miRNAs have been discovered and it seems that they regulate around 60 of human genesThrough a number of pathways miRNAs control the development re-modelling and regeneration of the heart as well as endothelial function vasculo-genesis and neoangiogenesis 30 of the genes in the human genome are regulated by about 1000 miRNAs Endogenous miRNAs are 19-22 nucleotide single-stranded RNA molecules that frequently target the 3 untranslated regions 3-UTR of mRNAs to regulate gene expression at the post-transcriptional level in physiological processes disease development and conditions like cancer autoimmune and inflammatory diseases neuro-degenerative diseases and cardiovascular diseases Cardiac-enriched miRNAs MiR-208 in health and disorders of the cardiovascular system are investigated
Identify new diagnostic biomarkers based on miRNAs researchers examine the expression of miR-133a and 208b at various time points 04 hours 08 hours 12 hours 24 hours 48 hours following the development of the infarct and compared it to the traditional myocardial infarction biomarkers cTnl and CK-MB
Identify new diagnostic biomarkers based on miRNAs researchers examine the expression of miR-133a and 208b at various time points 04 hours 08 hours 12 hours 24 hours 48 hours following the development of the infarct and compared it to the traditional myocardial infarction biomarkers cTnl and CK-MB
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None