Ignite Creation Date:
2024-05-06 @ 6:31 PM
Last Modification Date:
2024-10-26 @ 2:49 PM
Study NCT ID:
NCT05691205
Status:
RECRUITING
Last Update Posted:
2023-04-05
First Post:
2023-01-11
Brief Title:
Identifying Optimal PEEP After Lung Transplantation
Sponsor:
Policlinico Hospital
Organization:
Policlinico Hospital
Study Overview
Official Title:
Identifying the Optimal Positive End-Expiratory Pressure Level to Ventilate Patients After Bilateral Lung Transplantation
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PEEP-LuTX
Brief Summary:
Lung Transplantation LuTX is the curative treatment for selected patients with end-stage lung disease Primary Graft Dysfunction PGD a specific form of respiratory failure occurring within the first 72 hours after graft reperfusion represents the most common complication after LuTX
Actual recommendation regarding management of mechanical ventilation of the lung graft immediately after LuTX are based only on opinion experts and not on clinical trials Optimization of Positive End-Expiratory Pressure might contribute to both prevention and treatment of PGD
In this interventional single-center non-pharmacological study with medical device in the immediate postoperative period of patients who are undergone LuTX we will evaluate the effects of varying levels of PEEP upon - lung and chest wall mechanics - intrapulmonary shunt fraction - distribution of ventilation and perfusion - gas exchange
The final aim is to find the optimal level of PEEP in this patients cohort
Actual recommendation regarding management of mechanical ventilation of the lung graft immediately after LuTX are based only on opinion experts and not on clinical trials Optimization of Positive End-Expiratory Pressure might contribute to both prevention and treatment of PGD
In this interventional single-center non-pharmacological study with medical device in the immediate postoperative period of patients who are undergone LuTX we will evaluate the effects of varying levels of PEEP upon - lung and chest wall mechanics - intrapulmonary shunt fraction - distribution of ventilation and perfusion - gas exchange
The final aim is to find the optimal level of PEEP in this patients cohort
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None