Ignite Creation Date:
2024-05-06 @ 6:31 PM
Last Modification Date:
2024-10-26 @ 2:49 PM
Study NCT ID:
NCT05691985
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-01-17
First Post:
2023-01-11
Brief Title:
Fib to Alb Ratio in Type 2 Dkd
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Fibrinogen to Albumin Ratio FAR as a Risk Factor for Type 2 Diabetic NephropathyDN
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aimed to investigate the association of fibrinogen to albumin ratio FAR with DKD type 2 and to prove its possible role as a novel biomarker to predict and prevent DKD progression
Detailed Description:
Diabetic kidney disease DKD is the most prevalent chronic kidney disease Around 3540 of patients with type 2 diabetes mellitus T2DM will go on to develop DKD DKD is characterized by albuminuria and reduced estimated glomerular filtration rate eGFR both of which are independent risk factors for end-stage kidney disease ESKD cardiovascular events and death DKD accounts for a significant increase in mortality among diabetic patients and is a grave threat to their clinical outcome
Inflammation plays a major role in the development of DKD Serum fibrinogen FIB is a biomarker of coagulation and inflammation Elevated serum FIB is an independent risk factor of DKD progression to ESKD in patients with T2DM Albumin ALB has anti-inflammatory functions and antioxidant properties Hypoalbuminemia is associated with a poorer renal prognosis in patients with T2DM and DKD Fibrinogen to albumin ratio FAR is a more significant prognostic marker than each single marker itself in cancer study
Inflammation plays a major role in the development of DKD Serum fibrinogen FIB is a biomarker of coagulation and inflammation Elevated serum FIB is an independent risk factor of DKD progression to ESKD in patients with T2DM Albumin ALB has anti-inflammatory functions and antioxidant properties Hypoalbuminemia is associated with a poorer renal prognosis in patients with T2DM and DKD Fibrinogen to albumin ratio FAR is a more significant prognostic marker than each single marker itself in cancer study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None