Ignite Creation Date:
2024-05-06 @ 6:31 PM
Last Modification Date:
2024-10-26 @ 2:49 PM
Study NCT ID:
NCT05692804
Status:
RECRUITING
Last Update Posted:
2023-01-20
First Post:
2023-01-12
Brief Title:
Evaluation of Neuronal Damage in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy With Biomarkers
Sponsor:
Akdeniz University
Organization:
Akdeniz University
Study Overview
Official Title:
Evaluation of Intraoperative Neuronal Damage in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy With S100beta GFAP and NSE Biomarkers
Status:
RECRUITING
Status Verified Date:
2023-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Robotic assisted laparoscopic surgery has become an alternative to open or laparoscopic technique in various surgical fields Robot assisted laparoscopic surgery is preferred by surgeons and patients due to easy accessibility lower blood loss and lower transfusion rates However robotic assisted laparoscopic surgery can cause significant changes in cardiovascular respiratory metabolic and cerebral physiology because it requires a deep trendy position When long -lasting deep trendelenburg position is applied the cerebral autoregulation is impaired In the literature the presence of cases with brain edema is shown
In recent years many biomarkers have been used in the evaluation of brain damage S100 Calcium Binding Protein S100β N Ron specific enolase NSE Glial Fibrils are among the biomarkers used to show acidic protein GFAP brain damage The S100β is specific and is mainly produced by astrocytes and enters the bloodstream after neuron damage Glial fibrils is an acidic protein GFAP a protein encoded by the GFAP gene in humans an intermediate filament protein produced in the central nervous system Neuron specific enolase NSE is one of the enzymes that increase brain damage encoded by Enolase 2 ENO2 gene
Mini Mental State Examination and Montreal Cognitive Assessment will be performed to determine neurological changes developing in patients
The purpose of this study Robotic assisted laparoscopic surgery is to examine the brain damage that may develop in patients due to deep trendelenburg position in patients with the said biomarkers and to evaluate the anesthesia methods applied in these surgery in line with the study results
In recent years many biomarkers have been used in the evaluation of brain damage S100 Calcium Binding Protein S100β N Ron specific enolase NSE Glial Fibrils are among the biomarkers used to show acidic protein GFAP brain damage The S100β is specific and is mainly produced by astrocytes and enters the bloodstream after neuron damage Glial fibrils is an acidic protein GFAP a protein encoded by the GFAP gene in humans an intermediate filament protein produced in the central nervous system Neuron specific enolase NSE is one of the enzymes that increase brain damage encoded by Enolase 2 ENO2 gene
Mini Mental State Examination and Montreal Cognitive Assessment will be performed to determine neurological changes developing in patients
The purpose of this study Robotic assisted laparoscopic surgery is to examine the brain damage that may develop in patients due to deep trendelenburg position in patients with the said biomarkers and to evaluate the anesthesia methods applied in these surgery in line with the study results
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None