Ignite Creation Date:
2024-05-06 @ 6:31 PM
Last Modification Date:
2024-10-26 @ 2:49 PM
Study NCT ID:
NCT05688358
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-01-18
First Post:
2023-01-07
Brief Title:
Serum Interleukin - 17A in Juvenile Idiopathic Arthritis
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Serum Interleukin - 17A in Juvenile Idiopathic Arthritis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 This study aims to determine the serum levels of interleukin-17A IL-17A in children with juvenile idiopathic arthritis JIA
2 Analyze the correlation between IL-17A values and disease activity certain clinical features and laboratory markers of inflammation
2 Analyze the correlation between IL-17A values and disease activity certain clinical features and laboratory markers of inflammation
Detailed Description:
Juvenile Idiopathic Arthritis JIA is a group of chronic heterogenous disorders that manifests as joint inflammation in patients aged 16 years and lasts longer than 6 weeks Globally approximately 3 million children and young adults are suffering from JIA with prevalence rates consistently higher in girls The prevalence of JIA in Africa and Middle East was observed to be towards the lower range of the global estimate 1 The precise cause and pathogenesis of JIA are unknown however genetic environmental and autoimmune factors are hypothesized to play a role in its development 2 The condition can affect one or more joints and cause systemic symptoms such as fever or rash as well as extra-articular inflammatory signs such as uveitis3
The IL-17 cytokine superfamily is composed of 6 structurally related cytokines namely IL-17A-F The most investigated member of the family is IL-17A It is synthesized by Th17 cells γδ-T cells NK T cells lymphoid tissue inducer-like cells Paneth cells and neutrophils IL-17A plays important roles in protection from bacterial and fungal infections and in the development of autoimmune diseases 4
Recently a number of studies have been conducted on the role of IL-17A in the development of chronic arthritis It has a role both at the initial stages of joint inflammation and in the destruction of joint cartilage and bone structures5 It binds to its receptors on synoviocytes endothelial cells fibroblasts and osteoblasts and stimulates production of pro-inflammatory cytokines chemokines and other inflammatory mediators and also interacts synergistically with other pro- inflammatory cytokines such as IL-1 IL-6 and tumor necrosis factor alpha6
The IL-17 cytokine superfamily is composed of 6 structurally related cytokines namely IL-17A-F The most investigated member of the family is IL-17A It is synthesized by Th17 cells γδ-T cells NK T cells lymphoid tissue inducer-like cells Paneth cells and neutrophils IL-17A plays important roles in protection from bacterial and fungal infections and in the development of autoimmune diseases 4
Recently a number of studies have been conducted on the role of IL-17A in the development of chronic arthritis It has a role both at the initial stages of joint inflammation and in the destruction of joint cartilage and bone structures5 It binds to its receptors on synoviocytes endothelial cells fibroblasts and osteoblasts and stimulates production of pro-inflammatory cytokines chemokines and other inflammatory mediators and also interacts synergistically with other pro- inflammatory cytokines such as IL-1 IL-6 and tumor necrosis factor alpha6
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None