Ignite Creation Date:
2024-05-06 @ 6:30 PM
Last Modification Date:
2024-10-26 @ 2:49 PM
Study NCT ID:
NCT05680701
Status:
RECRUITING
Last Update Posted:
2023-03-15
First Post:
2022-12-19
Brief Title:
Modulating Cortical Dynamics of Dual-task Standing in MCI
Sponsor:
Hebrew SeniorLife
Organization:
Hebrew SeniorLife
Study Overview
Official Title:
Understanding and Modulating Cortical Dynamics of Dual-task Standing in Older Adults With Mild Cognitive Impairment
Status:
RECRUITING
Status Verified Date:
2023-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators have designed a brain stimulation study to understand its effect on an individuals standing walking and thinking abilities in older adults with and without mild cognitive impairments MCI The transcranial alternating current stimulation tACS technology has been safely and effectively used in hundreds of individuals The purpose of this study is to test whether a single session of tACS as compared to sham intervention improves standing walking and thinking in older adults with and without mild cognitive impairments MCI Approximately 60 people will take part in this study
Detailed Description:
Mild Cognitive Impairment MCI represents a common prodromal phase of dementia1 As compared to older adults who are cognitively-intact those with MCI tend to exhibit poor dual-task standing balance performance that is the ability to maintain balance when standing and simultaneously performing an unrelated cognitive task Moreover those older adults who have worse dual-task standing balance are more likely to suffer falls and develop dementia As such strategies designed to understand and enhance the brain functionality involved in dual-task standing balance hold great promise to improve daily life function and potentially reduce the risk of dementia in this population
Surface electroencephalography EEG allows non-invasive assessment of brain activity dynamics over short periods of time even when standing It has been demonstrated in younger and older adults that dual-task standing is associated with brain activity fluctuations at specific frequencies A recent study from our laboratory demonstrated that in older adults 1 performance of a serial subtraction cognitive task when standing reduces fronto-central alpha power ie fluctuations in the 8-13 Hz band and 2 those with lower fronto-central alpha power when dual tasking exhibit worse dual task standing balance Intriguingly numerous studies have separately linked diminished alpha activity with worse performance on executive function and visuomotor tasks as well as global cognitive decline in older adults We therefore contend that therapeutic strategies designed to increase alpha activity hold promise to improve dual-task standing performance and many other cognitive-motor functions in older adults with and without MCI To date however the effects of enhancing fronto-central alpha activity to improve dual-task balance in older adults with and without MCI have not been studied
Transcranial alternating stimulation tACS is a safe non-invasive brain stimulation technique that utilizes low-amplitude alternating currents to modulate brain activity and entrain specific cortical rhythms depending on the applied stimulation frequency Targeting alpha band 10 Hz in the frontal region has been shown to improve cognitive functioning in healthy older adults However no studies have investigated the effect of 10 Hz fronto-central stimulation on EEG alpha activity and postural sway outcomes during dual-task standing in older adults with and without MCI We thus propose to conduct a within-subject cross-over sham-controlled study in 30 older adults without an overt disease and 30 older adults with MCI Participants will undergo dual-task standing and cognitive assessments immediately before and after single sessions of 10 Hz tACS fronto-central alpha stimulation and active-sham to understand the effect of different stimulation parameters on dual-task standing performance in older adults We hypothesize that 1 older adults with MCI will demonstrate decreased EEG alpha power during dual-task standing compared to healthy controls and decreased alpha power will be associated with worse balance outcomes during dual-task standing and 2 compared to the pre-stimulation condition participants will exhibit a greater increase in alpha power during the dual-task standing condition following tACS as compared to sham stimulation and the increase in alpha power from pre-to-post tACS will correlate with a decrease in dual-task postural sway speed from pre-to-post tACS in older adults with and without MCI
Surface electroencephalography EEG allows non-invasive assessment of brain activity dynamics over short periods of time even when standing It has been demonstrated in younger and older adults that dual-task standing is associated with brain activity fluctuations at specific frequencies A recent study from our laboratory demonstrated that in older adults 1 performance of a serial subtraction cognitive task when standing reduces fronto-central alpha power ie fluctuations in the 8-13 Hz band and 2 those with lower fronto-central alpha power when dual tasking exhibit worse dual task standing balance Intriguingly numerous studies have separately linked diminished alpha activity with worse performance on executive function and visuomotor tasks as well as global cognitive decline in older adults We therefore contend that therapeutic strategies designed to increase alpha activity hold promise to improve dual-task standing performance and many other cognitive-motor functions in older adults with and without MCI To date however the effects of enhancing fronto-central alpha activity to improve dual-task balance in older adults with and without MCI have not been studied
Transcranial alternating stimulation tACS is a safe non-invasive brain stimulation technique that utilizes low-amplitude alternating currents to modulate brain activity and entrain specific cortical rhythms depending on the applied stimulation frequency Targeting alpha band 10 Hz in the frontal region has been shown to improve cognitive functioning in healthy older adults However no studies have investigated the effect of 10 Hz fronto-central stimulation on EEG alpha activity and postural sway outcomes during dual-task standing in older adults with and without MCI We thus propose to conduct a within-subject cross-over sham-controlled study in 30 older adults without an overt disease and 30 older adults with MCI Participants will undergo dual-task standing and cognitive assessments immediately before and after single sessions of 10 Hz tACS fronto-central alpha stimulation and active-sham to understand the effect of different stimulation parameters on dual-task standing performance in older adults We hypothesize that 1 older adults with MCI will demonstrate decreased EEG alpha power during dual-task standing compared to healthy controls and decreased alpha power will be associated with worse balance outcomes during dual-task standing and 2 compared to the pre-stimulation condition participants will exhibit a greater increase in alpha power during the dual-task standing condition following tACS as compared to sham stimulation and the increase in alpha power from pre-to-post tACS will correlate with a decrease in dual-task postural sway speed from pre-to-post tACS in older adults with and without MCI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None