Ignite Creation Date:
2024-05-06 @ 6:28 PM
Last Modification Date:
2024-10-26 @ 2:48 PM
Study NCT ID:
NCT05673135
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-24
First Post:
2023-01-01
Brief Title:
The Outcomes of Hypertension in Obese Versus Non-obese Pregnant Women
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
The Differences in Adverse Maternal and Fetal Outcomes Related to Hypertension in Obese Versus Non-obese Pregnant Women
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hypertensive disorders of pregnancy include pre-existing and gestational hypertension preeclampsia and eclampsia it complicates up to 10 of pregnancies and represents a significant cause of maternal and perinatal morbidity and mortality Following the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy recommendation is currently a systolic blood pressure SBP of 140 mmHg and diastolic blood pressure DBP of 90 mmHg The diagnosis generally requires two separate measurements Accepted across international guidelines are the following four categories Chronicpre-existing hypertension Hypertension discovered preconception or prior to 20 weeks gestation Gestational hypertension Hypertension that appears de novo after 20 weeks gestation and normalizes after pregnancy Preeclampsia-eclampsia De novo hypertension after 20 weeks gestation accompanied by proteinuria other features of maternal organ dysfunction or uteroplacental dysfunction Chronicpre-existing hypertension with superimposed preeclampsia-eclampsia Over the past 2 decades extensive epidemiologic studies have clearly established that obesity is a major risk for gestational hypertension and preeclampsia The risk of preeclampsia typically doubles with each 5-7 kgm2 increase in pre-pregnancy The mechanisms have only been partially explored increased cytokine-mediated inflammation and oxidative stress increased shear stress dyslipidemia and increased sympathetic activity1 have all been proposed as possible pathways Few studies have examined the relationship between pre-pregnancy BMI gestational weight gain GWG and the risk of preeclampsia So our study aims to evaluate the adverse maternal and fetal outcomes related to hypertension in obese and non-obese pregnant women
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None