Ignite Creation Date:
2024-05-06 @ 6:25 PM
Last Modification Date:
2024-10-26 @ 2:47 PM
Study NCT ID:
NCT05654727
Status:
COMPLETED
Last Update Posted:
2022-12-19
First Post:
2022-12-08
Brief Title:
Cognitive Functions and BDNF in T2DM and Prediabetes Patients
Sponsor:
Bezmialem Vakif University
Organization:
Bezmialem Vakif University
Study Overview
Official Title:
Cognitive Impairment and BDNF in Patients With Diabetes and Prediabetes
Status:
COMPLETED
Status Verified Date:
2022-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Clinical and epidemiological studies suggest links between cognitive impairments and Type 2 diabetes T2DM The underlying mechanisms and causality in diabetes-related cognitive impairment are largely unknown The aim of this study is to investigate cognitive impairment and the role of BDNF in prediabetes and diabetes patients
Detailed Description:
Cognitive dysfunction is increasingly recognized as a common complication and comorbidity in both type 1 and type 2 diabetes T2DM Due to the increasing incidence of diabetes and the life expectancy of individuals with T2DM it is important to determine the cognitive problems and related factors in these patients Cognitive impairment can be observed in all age groups in individuals with diabetes and its severity can range from mild cognitive impairment to dementia Although there are few studies in the literature investigating cognitive impairment in prediabetes it is not clear whether it is a risk factor
The number of studies investigating biomarkers of potential importance for understanding changes in the brain of T2DM patients is increasing rapidly The relationship of biomarkers associated with the main pathologies of dementia including Alzheimers disease AD and vascular disease as well as various biomarkers associated with brain parenchymal damage blood flow and metabolism with the cognitive status of diabetic patients are investigated It has been determined in animal experiments that Brain Induced Neurotrophic Factor BDNF may be among the molecular factors linking T2DM with dementia neuropathology It has also been stated that high glucose levels are associated with cognitive impairment and total hippocampal volume reductions and hippocampal changes can be used as an early marker of diabetes-related brain damage Considering that the expression of BDNF in the brain is high in hippocampus neurons it may be an early marker of cognitive impairment in diabetes
This research is a cross-sectional observational study The aim of this study is to investigate cognitive impairment and the role of BDNF in prediabetes and diabetes patients
The number of studies investigating biomarkers of potential importance for understanding changes in the brain of T2DM patients is increasing rapidly The relationship of biomarkers associated with the main pathologies of dementia including Alzheimers disease AD and vascular disease as well as various biomarkers associated with brain parenchymal damage blood flow and metabolism with the cognitive status of diabetic patients are investigated It has been determined in animal experiments that Brain Induced Neurotrophic Factor BDNF may be among the molecular factors linking T2DM with dementia neuropathology It has also been stated that high glucose levels are associated with cognitive impairment and total hippocampal volume reductions and hippocampal changes can be used as an early marker of diabetes-related brain damage Considering that the expression of BDNF in the brain is high in hippocampus neurons it may be an early marker of cognitive impairment in diabetes
This research is a cross-sectional observational study The aim of this study is to investigate cognitive impairment and the role of BDNF in prediabetes and diabetes patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None