Ignite Creation Date:
2024-05-05 @ 6:39 PM
Last Modification Date:
2024-10-26 @ 9:35 AM
Study NCT ID:
NCT00523562
Status:
COMPLETED
Last Update Posted:
2018-06-14
First Post:
2007-08-30
Brief Title:
Effects of Macronutrients on Hepatic Lipids Plasma Triglycerides and Insulin Sensitivity
Sponsor:
University of Lausanne
Organization:
University of Lausanne
Study Overview
Official Title:
Study of the Role of Insulin Resistance in the Pathogenesis of the Metabolic Syndrome and of Non-alcoholic Steatohepatitis
Status:
COMPLETED
Status Verified Date:
2018-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MACRONUTR
Brief Summary:
The purpose of this study is to assess how the macronutrient composition of the diet effects
lipid and glucose metabolism
intrahepatic lipids
insulin sensitivity
in healthy lean subjects and in subjects with a high metabolic risk ie overweight and offsprings of patients with type 2 diabetes mellitus
lipid and glucose metabolism
intrahepatic lipids
insulin sensitivity
in healthy lean subjects and in subjects with a high metabolic risk ie overweight and offsprings of patients with type 2 diabetes mellitus
Detailed Description:
The study is aimed at assessing the effects of changes in total energy sugars lipids and protein intake on intrahepatic lipids plasma lipids and hepatic and whole body insulin resistance in
lean men and women with no family history of diabetes
overweight men and women
lean men with a family history of type 2 diabetes
Subjects are studied after a 6-day period of
isocaloric diet with 100 calorie requirement of which 55 carbohydrate 15 protein and 30 fat
the same isocaloric diet supplemented with 3gkg body weightday fructose
hypercaloric high fat diet with 130 energy requirement of which 55 carbohydrate 15 protein 60 fat
hypercaloric high fatprotein diet with 145 energy requirement of which 55 carbohydrate 30 protein 60 fat
Measurements performed after 6 days on each diet include
intrahepatic and intramyocellular lipids 1H-MRS
hepatic and whole body insulin sensitivity hyperinsulinemic-euglycemic clamp
body weight
plasma concentrations of hormones and substrates
gene expression profile in skeletal muscle vastus lateralis and adipose tissue subcutaneous abdominal
lean men and women with no family history of diabetes
overweight men and women
lean men with a family history of type 2 diabetes
Subjects are studied after a 6-day period of
isocaloric diet with 100 calorie requirement of which 55 carbohydrate 15 protein and 30 fat
the same isocaloric diet supplemented with 3gkg body weightday fructose
hypercaloric high fat diet with 130 energy requirement of which 55 carbohydrate 15 protein 60 fat
hypercaloric high fatprotein diet with 145 energy requirement of which 55 carbohydrate 30 protein 60 fat
Measurements performed after 6 days on each diet include
intrahepatic and intramyocellular lipids 1H-MRS
hepatic and whole body insulin sensitivity hyperinsulinemic-euglycemic clamp
body weight
plasma concentrations of hormones and substrates
gene expression profile in skeletal muscle vastus lateralis and adipose tissue subcutaneous abdominal
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None