Ignite Creation Date:
2024-05-06 @ 6:23 PM
Last Modification Date:
2024-10-26 @ 2:47 PM
Study NCT ID:
NCT05645770
Status:
UNKNOWN
Last Update Posted:
2022-12-12
First Post:
2022-12-01
Brief Title:
Prospective Memory and Cardiac Activity in Coronary Artery Disease
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Prospective Memory and Cardiac Activity in Coronary Artery Disease
Status:
UNKNOWN
Status Verified Date:
2022-09
Last Known Status:
ENROLLING_BY_INVITATION
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Previous studies demonstrated an association between cognitive deficit and coronary artery disease CAD Abete et al 2014 Deckers et al 2017 even after controlling for the effects of age and socioeconomic status Singh-Manoux et al 2003 A selective non-amnestic cognitive impairment profile has also been observed in this patient group Roberts et al 2010 with executive function as the most vulnerable cognitive domain Rostamian et al 2015
Prospective memory and CAD Prospective memory PM is another facet of executive function that concerns the realization of an intended action Kvavilashvili 1998 In addition to the support from memory system PM strongly relies on attentional and executive control Kliegel et al 2011 For example the two-stage cue-focused view of PM retrieval McDaniel et al 2004 posited the importance of noticing an action cue before the associated memory search can be initiated PM is a clinically relevant psychological construct as the failure has been related to quality of life Doyle et al 2012 activities of daily living Woods et al 2008 and medication adherence Zogg et al 2012
However little is known about PM function in CAD Only Habota et al 2015 reported significant PM deficit in a small group of chronic heart failure patients N 19 as compared to healthy controls N 24 Therefore the first aim of the present study is to examine PM performance in people with CAD as compared to their healthy controls
Prospective memory and cardiac function The association between the brain and the heart has long been recognized Samuels 2007 However the mechanism of cognitive impairment in CAD has not been clearly understood Researchers proposed several contributing pathological routes including increased platelet activity thrombo-embolic mechanisms or cardiac output reduction Abete et al 2014 The neurovisceral integration model Smith et al 2017 proposed a hierarchy of vagal control from intra-cardiac and cardiovascular reactions to representation of multimodal prior expectations that involve the cerebral executive control network Accumulating evidence supported this notion by demonstrating the link between autonomic nervous system ANS and behavioral performance such as the association between heart rate variability HRV and cognitive functions Forte et al 2019 and its moderating effect of resting pre-ejection time PEP Giuliano et al 2017
Few studies investigated the relationship between autonomic responses and PM Kliegel et al 2007 and Rothen et al 2014 verified that there was an association between increased skin conductance responses SCRs and the noticing of PM cues in young adults More recently Umeda et al 2016 found that PM performance was associated with an increase in heart rate upon target presentation and with better interoceptive accuracy in college students They hypothesized that PM was regulated by cardiac afferent signals that facilitate saliency detection and intention retrieval which was also mediated by interoceptive accuracy These preliminary findings suggest close relationship between PM and autonomic functions and provide another aspect of the evidence on the brain-heart connection
However the methodology adopted in these studies suffered from crude indirect measures of ANS activity It is also unclear if the autonomic nervous function compromised by CAD Montano et al 2009 would play a role in PM deficit Hence the second aim of the present study is to investigate the relationship between PM and cardiac function as measured by HF-HRV the parasympathetic component and PEP the sympathetic component
Prospective memory and CAD Prospective memory PM is another facet of executive function that concerns the realization of an intended action Kvavilashvili 1998 In addition to the support from memory system PM strongly relies on attentional and executive control Kliegel et al 2011 For example the two-stage cue-focused view of PM retrieval McDaniel et al 2004 posited the importance of noticing an action cue before the associated memory search can be initiated PM is a clinically relevant psychological construct as the failure has been related to quality of life Doyle et al 2012 activities of daily living Woods et al 2008 and medication adherence Zogg et al 2012
However little is known about PM function in CAD Only Habota et al 2015 reported significant PM deficit in a small group of chronic heart failure patients N 19 as compared to healthy controls N 24 Therefore the first aim of the present study is to examine PM performance in people with CAD as compared to their healthy controls
Prospective memory and cardiac function The association between the brain and the heart has long been recognized Samuels 2007 However the mechanism of cognitive impairment in CAD has not been clearly understood Researchers proposed several contributing pathological routes including increased platelet activity thrombo-embolic mechanisms or cardiac output reduction Abete et al 2014 The neurovisceral integration model Smith et al 2017 proposed a hierarchy of vagal control from intra-cardiac and cardiovascular reactions to representation of multimodal prior expectations that involve the cerebral executive control network Accumulating evidence supported this notion by demonstrating the link between autonomic nervous system ANS and behavioral performance such as the association between heart rate variability HRV and cognitive functions Forte et al 2019 and its moderating effect of resting pre-ejection time PEP Giuliano et al 2017
Few studies investigated the relationship between autonomic responses and PM Kliegel et al 2007 and Rothen et al 2014 verified that there was an association between increased skin conductance responses SCRs and the noticing of PM cues in young adults More recently Umeda et al 2016 found that PM performance was associated with an increase in heart rate upon target presentation and with better interoceptive accuracy in college students They hypothesized that PM was regulated by cardiac afferent signals that facilitate saliency detection and intention retrieval which was also mediated by interoceptive accuracy These preliminary findings suggest close relationship between PM and autonomic functions and provide another aspect of the evidence on the brain-heart connection
However the methodology adopted in these studies suffered from crude indirect measures of ANS activity It is also unclear if the autonomic nervous function compromised by CAD Montano et al 2009 would play a role in PM deficit Hence the second aim of the present study is to investigate the relationship between PM and cardiac function as measured by HF-HRV the parasympathetic component and PEP the sympathetic component
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None