Ignite Creation Date:
2024-05-06 @ 6:22 PM
Last Modification Date:
2024-10-26 @ 2:47 PM
Study NCT ID:
NCT05643547
Status:
NOT_YET_RECRUITING
Last Update Posted:
2022-12-08
First Post:
2022-11-30
Brief Title:
Immunophenotypic Evaluation of IL-7R α in Acute Leukaemia
Sponsor:
Rania Abdeltwab Abdelazeim
Organization:
Assiut University
Study Overview
Official Title:
Immunophenotypic Evaluation of IL-7R α in Acute Leukaemia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2022-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute leukemia is generally understood to be a neoplastic process that exerts a maturational block at a hematopoietic precursor cell level accompanied by a proliferative drive of varying degree The resulting accumulation of cells most frequently in the marrow causes the typical clinical picture which includes marrow failure tissue infiltration organomegaly and on occasion tumor masses AL is broadly classified as acute myeloid leukemia AML and acute lymphoid leukemia ALL 1
Acute lymphoblastic leukemia is frequently diagnosed in children and young adults with incidence peaks between 2 and 5 years of age 2 whereas AML is the most common acute type in adults 3
In addition to leukemia cells themselves cells of the immune system are a fundamental component of the tumor microenvironment TME which often modify the TME to be more favorable to tumor development and progression through producing cytokines and mediators 45 Interleukins interleukin receptors interaction plays important roles in the antitumor immune response through mediating cell-cell communication in TME and is reported to be relevant to patient prognosis 67 As a member of the Interleukin family Interleukin 7 IL7 play vital roles in hematopoiesis and the development of T lymphocytes as well as the inflammation autoimmune diseases and hematological cancers Its function is mediated by the IL7 R which is a membrane receptor consisted of the specific IL7Ra chain CD127 and IL-7Rγ chain common gamma chain shared by the receptors for IL-2-4-9-15 and-21 8 It is thus not surprising that activation of IL-7 signalling is seen in the majority of T-ALLs and in some of the B cell precursor ALL 910
Consistent with the absolute requirement of IL-7 to human T cell development most T-ALLs have been shown to respond to IL-7 Thus targeting IL-7 signaling might be a reasonable general approach for treatment of T-ALL regardless the presence of activating mutations 10
Acute lymphoblastic leukemia is frequently diagnosed in children and young adults with incidence peaks between 2 and 5 years of age 2 whereas AML is the most common acute type in adults 3
In addition to leukemia cells themselves cells of the immune system are a fundamental component of the tumor microenvironment TME which often modify the TME to be more favorable to tumor development and progression through producing cytokines and mediators 45 Interleukins interleukin receptors interaction plays important roles in the antitumor immune response through mediating cell-cell communication in TME and is reported to be relevant to patient prognosis 67 As a member of the Interleukin family Interleukin 7 IL7 play vital roles in hematopoiesis and the development of T lymphocytes as well as the inflammation autoimmune diseases and hematological cancers Its function is mediated by the IL7 R which is a membrane receptor consisted of the specific IL7Ra chain CD127 and IL-7Rγ chain common gamma chain shared by the receptors for IL-2-4-9-15 and-21 8 It is thus not surprising that activation of IL-7 signalling is seen in the majority of T-ALLs and in some of the B cell precursor ALL 910
Consistent with the absolute requirement of IL-7 to human T cell development most T-ALLs have been shown to respond to IL-7 Thus targeting IL-7 signaling might be a reasonable general approach for treatment of T-ALL regardless the presence of activating mutations 10
Detailed Description:
Acute leukemia is generally understood to be a neoplastic process that exerts a maturational block at a hematopoietic precursor cell level accompanied by a proliferative drive of varying degree The resulting accumulation of cells most frequently in the marrow causes the typical clinical picture which includes marrow failure tissue infiltration organomegaly and on occasion tumor masses AL is broadly classified as acute myeloid leukemia AML and acute lymphoid leukemia ALL 1
Acute lymphoblastic leukemia is frequently diagnosed in children and young adults with incidence peaks between 2 and 5 years of age 2 whereas AML is the most common acute type in adults 3
In addition to leukemia cells themselves cells of the immune system are a fundamental component of the tumor microenvironment TME which often modify the TME to be more favorable to tumor development and progression through producing cytokines and mediators 45 Interleukins interleukin receptors interaction plays important roles in the antitumor immune response through mediating cell-cell communication in TME and is reported to be relevant to patient prognosis 67 As a member of the Interleukin family Interleukin 7 IL7 play vital roles in hematopoiesis and the development of T lymphocytes as well as the inflammation autoimmune diseases and hematological cancers Its function is mediated by the IL7 R which is a membrane receptor consisted of the specific IL7Ra chain CD127 and IL-7Rγ chain common gamma chain shared by the receptors for IL-2-4-9-15 and-21 8 It is thus not surprising that activation of IL-7 signalling is seen in the majority of T-ALLs and in some of the B cell precursor ALL 910
Consistent with the absolute requirement of IL-7 to human T cell development most T-ALLs have been shown to respond to IL-7 Thus targeting IL-7 signaling might be a reasonable general approach for treatment of T-ALL regardless the presence of activating mutations 10
Acute lymphoblastic leukemia is frequently diagnosed in children and young adults with incidence peaks between 2 and 5 years of age 2 whereas AML is the most common acute type in adults 3
In addition to leukemia cells themselves cells of the immune system are a fundamental component of the tumor microenvironment TME which often modify the TME to be more favorable to tumor development and progression through producing cytokines and mediators 45 Interleukins interleukin receptors interaction plays important roles in the antitumor immune response through mediating cell-cell communication in TME and is reported to be relevant to patient prognosis 67 As a member of the Interleukin family Interleukin 7 IL7 play vital roles in hematopoiesis and the development of T lymphocytes as well as the inflammation autoimmune diseases and hematological cancers Its function is mediated by the IL7 R which is a membrane receptor consisted of the specific IL7Ra chain CD127 and IL-7Rγ chain common gamma chain shared by the receptors for IL-2-4-9-15 and-21 8 It is thus not surprising that activation of IL-7 signalling is seen in the majority of T-ALLs and in some of the B cell precursor ALL 910
Consistent with the absolute requirement of IL-7 to human T cell development most T-ALLs have been shown to respond to IL-7 Thus targeting IL-7 signaling might be a reasonable general approach for treatment of T-ALL regardless the presence of activating mutations 10
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None