Ignite Creation Date:
2024-05-05 @ 6:38 PM
Last Modification Date:
2024-10-26 @ 9:36 AM
Study NCT ID:
NCT00527384
Status:
COMPLETED
Last Update Posted:
2015-04-14
First Post:
2007-09-06
Brief Title:
Biomarker Analysis of Stress
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
Biomarker Signatures of Biological Chemical or Psychological Stress
Status:
COMPLETED
Status Verified Date:
2015-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Physiological changes can occur from different types of stress as induced by an infection an environmental toxicant exposure or an emotional disturbance The stress-induced effects can modify health by lessening defense mechanisms as maintained by the immune system The ability of different forms of stress to alter physiological processes body functions will be assessed by monitoring the blood profile of cell numbers and functions as well as the plasma protein content It is anticipated that the pattern of blood changes will reflect the types of stress and the degree to which body functions could be altered by the stress
Detailed Description:
Blood will be collected from patients with an ongoing infection that has lead to sepsis systemic inflammation as a index of major stress The blood will be analyzed for the types of proteins that could alter immune system functions and affect organ functions including cardiovascular effects due to blood vessel changes This will be followed by analysis of stress effects on mice and mice that have been generated with human immune cells The ability of stress to alter blood patterns will also be examined in mice with genetic modification of metallothionein expression which is believe to influence oxidative stress
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None