Viewing Study NCT05632614



Ignite Creation Date: 2024-05-06 @ 6:21 PM
Last Modification Date: 2024-10-26 @ 2:46 PM
Study NCT ID: NCT05632614
Status: RECRUITING
Last Update Posted: 2024-04-09
First Post: 2022-10-12

Brief Title: Blood Flow Reserve Effects After Training With Heavy Inspiratory Exercises
Sponsor: Ottawa Heart Institute Research Corporation
Organization: Ottawa Heart Institute Research Corporation

Study Overview

Official Title: The Efficacy of Inspiratory Muscle Strength Training on Coronary Blood Flow in Patients With Coronary Artery Disease
Status: RECRUITING
Status Verified Date: 2024-04
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: BREATHE
Brief Summary: The goal of this single-site parallel-group double-blind sham-controlled randomized control trial is to examine the effect of high-intensity inspiratory muscle strength training IMST on coronary blood flow assessed using positron emission tomography coronary perfusion imaging in patients with coronary artery disease CAD

The main question it aims to answer are

if high-intensity IMST will improve coronary blood flow in patients with CAD which could be assessed using positron emission tomography coronary perfusion imaging

Participants will be asked to complete the 8-week high-intensity or low-intensity IMST Researchers will compare high and low-intensity IMST groups to see if coronary blood flow increases after IMST
Detailed Description: Coronary artery disease CAD is a leading cause of morbidity and mortality With the aging population increasing number of patients with CAD has frailty and immobility The health benefits of traditional aerobic exercise have been well-established however alternative exercise programs such as inspiratory muscle training IMST may provide greater merits IMST is a form of exercise that engages the diaphragm and accessory respiratory muscles to repeatedly inhale against resistance which can be achieved in less time and widely applicable even for immobile or frail patients compared to conventional aerobic exercise Since barriers to conventional exercise training include immobility lack of time and access to facilities IMST may be a beneficial exercise form that can overcome those factors A previous study has shown that high-intensity IMT can lower blood pressure and improved vascular endothelial function Improvements in endothelial function of coronary arteries could improve coronary blood flow leading to the improvement of anginal symptoms as well as quality of life IMST might offer a widely applicable feasible time-efficient form of training for CAD patients Our study will examine the preliminary efficacy of IMST on coronary blood flow in patients with CAD

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None