Ignite Creation Date:
2024-05-06 @ 6:20 PM
Last Modification Date:
2024-10-26 @ 2:45 PM
Study NCT ID:
NCT05623293
Status:
RECRUITING
Last Update Posted:
2022-11-21
First Post:
2021-08-15
Brief Title:
Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis
Sponsor:
Universidade do Porto
Organization:
Universidade do Porto
Study Overview
Official Title:
Prognostic Predictors of Cardiovascular and Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis Undergoing Carotid Endarterectomy With Regional Anesthesia - A Prospective Study
Status:
RECRUITING
Status Verified Date:
2022-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The retinal vessels have been shown to reflect vascular changes inherent to systemic pathologies even when no ocular disease is identified As such the eyes vasculature is ableto serve as a window to the vascular health of the human body and a means of assessing systemic endothelial function Optical coherence tomography angiography OCTA employs optical means to image all the retinal vascular layers and the choroid providing an extremely detailed image of the microvascular network in a fast reproducible and totally non-invasive way As such it is currently the best non-invasive way of having an image of human capillaries Recently OCTA has been used to study the retinal vessels structure and function in several cardiovascular diseases As an example of its predictive potential reduced retinal microvascular density has been associated with the cardiovascular risk profile in patients admitted to the hospital for an acute coronary syndrome Recent studies have also shown the retinal microvasculature density to be reduced in patients with carotid artery disease CAD namely carotid stenosis and that endarterectomy increases retinal flow and vessel density
Detailed Description:
The authors hypothesize that FGF-23 GDF-15 VEGF-A MMP-9 and retinalchoroidal microvascular density could predict cerebral ischemia postoperative complications long term major cardiovascular events and short term ophthalmologic alterations particularly in patients developing symptomatic neurologic ischemia after circulation shutdown
The purpose of this study is to compare different cardiac risk scores in carotid endarterectomy The main aim of this study is to test the risk factors individually and determine its discriminatory ability Combinations of traditional preoperative risk factors and scores will be evaluated to enhance the assessment of major adverse cardiac events in vascular surgery patients
Establish and validate biomarkers that improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization outperform existing biomarkers and reach clinical application standards
The purpose of this study is to compare different cardiac risk scores in carotid endarterectomy The main aim of this study is to test the risk factors individually and determine its discriminatory ability Combinations of traditional preoperative risk factors and scores will be evaluated to enhance the assessment of major adverse cardiac events in vascular surgery patients
Establish and validate biomarkers that improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization outperform existing biomarkers and reach clinical application standards
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None