Ignite Creation Date:
2024-05-06 @ 6:19 PM
Last Modification Date:
2024-10-26 @ 2:45 PM
Study NCT ID:
NCT05622838
Status:
NOT_YET_RECRUITING
Last Update Posted:
2022-11-22
First Post:
2022-11-04
Brief Title:
Maternal alpha1 Antitrypsin as a Marker of Intrauterine Growth Restriction in Pre-eclamptic Women
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Maternal alpha1 Antitrypsin as a Marker of Intrauterine Growth Restriction in Pre-eclamptic Women
Status:
NOT_YET_RECRUITING
Status Verified Date:
2022-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Intrauterine growth restriction IUGR is defined as a velocity of fetal growth less than the normal fetus growth potential for a specific neonate as per the race and gender These neonates face many acute problems during peripartum and after birth The causes of IUGR may be maternal placental fetal or genetic and also due to combination of any of these factors Knowledge of etiologies of fetal growth restriction FGR is essential so that future care can be targeted at prevention It is apparent that FGR is primarily caused by placental dysfunction PIHPE insufficiency that lead to reduced fetal growth overall FGR is associated with lifelong burden of chronic diseases including metabolic respiratory cardiovascular and neurological deficits Pre-eclampsia PE is diagnosed by the combined presentation of high blood pressure and proteinuria New definitions also include maternal organ dysfunction such as renal liver neurological or haematological complications uteroplacental dysfunction or FGR In an attempt to correct fetus reduced supply the placenta release various cytokines and markers as Alpha-1 anti-trypsin AAT The Golgi apparatus secretes this cytokine in placental cytotrophoblast and blood vessels AAT is antinflammatory antiprotease protective molecule AAT rises during normal pregnancy The suboptimal rise of AAT in pregnancy are liable for increased obstetrical complications like abortion preterm labor AAT levels were found decreased in placenta tissues from women with PE compared that of healthy women Although AAT deficiency is associated with several pregnancy and placental disorders little is known regarding AAT levels and PE
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None