Ignite Creation Date:
2024-05-05 @ 6:38 PM
Last Modification Date:
2024-10-26 @ 9:35 AM
Study NCT ID:
NCT00512343
Status:
RECRUITING
Last Update Posted:
2023-12-12
First Post:
2007-08-03
Brief Title:
Synovial Fluid Bank From Arthritic Patients
Sponsor:
Gilles Boire
Organization:
Université de Sherbrooke
Study Overview
Official Title:
Establishment of a Bank of Synovial Fluids and Paired Sera From Arthritic Patients for the Evaluation of New Methods Facilitating the Diagnosis and the Monitoring of Progression and Therapy of Arthritis
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objectives of this group project is to collect synovial fluid SF and paired sera and carry out preclinical studies to evaluate alone or by combination testings the potential of novel biomarkers for their prevalence and diagnosticprognostic values in patients with arthritis and to determine how therapeutic intervention regulate their levels
Detailed Description:
Our group has developed interdisciplinary expertise in biomarkers related to distinct aspects of inflammation-induced joint damage most notably those associated with degradation of components of the extracellular matrix bone loss or associated with post-translational changes on protease inhibitors
The objectives of this group project is to collect SF and paired sera and carry out preclinical studies to evaluate alone or by combination testings the potential of novel biomarkers for their prevalence and diagnosticprognostic values in patients with arthritis and to determine how therapeutic intervention regulate their levels
More specifically we will study 1 biomarkers associated with osteoclastic bone resorption and synthesisdegradation of cartilage 2 inhibitors of enzymes calpastatin that are preferentially targeted by rheumatoid patients as well as 3 enzymes eg Matrix Metalloproteinases MMPs responsible for the cleavage of components of the articular cartilage
Finally we propose to characterize the repertoire of specific active proteases in the SF of arthritic patients concomitantly to the use biomarkers neoepitopes of cleaved collagens previously associated with cartilage destruction and synthesis to identify new targets for the development of protease inhibitors for the treatment of arthritis Furthermore our project will also provide the opportunity to test the potential of measuring the net proteolytic activity by Fluorescent-Activated Substrate Conversion as a method of monitoring disease activity and treatment efficiency in a clinical setting
The objectives of this group project is to collect SF and paired sera and carry out preclinical studies to evaluate alone or by combination testings the potential of novel biomarkers for their prevalence and diagnosticprognostic values in patients with arthritis and to determine how therapeutic intervention regulate their levels
More specifically we will study 1 biomarkers associated with osteoclastic bone resorption and synthesisdegradation of cartilage 2 inhibitors of enzymes calpastatin that are preferentially targeted by rheumatoid patients as well as 3 enzymes eg Matrix Metalloproteinases MMPs responsible for the cleavage of components of the articular cartilage
Finally we propose to characterize the repertoire of specific active proteases in the SF of arthritic patients concomitantly to the use biomarkers neoepitopes of cleaved collagens previously associated with cartilage destruction and synthesis to identify new targets for the development of protease inhibitors for the treatment of arthritis Furthermore our project will also provide the opportunity to test the potential of measuring the net proteolytic activity by Fluorescent-Activated Substrate Conversion as a method of monitoring disease activity and treatment efficiency in a clinical setting
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None