Ignite Creation Date:
2024-05-06 @ 6:19 PM
Last Modification Date:
2024-10-26 @ 2:46 PM
Study NCT ID:
NCT05623540
Status:
COMPLETED
Last Update Posted:
2022-11-22
First Post:
2022-11-13
Brief Title:
Bisphosphonates Use After Total Joint Arthroplasty
Sponsor:
National Defense Medical Center Taiwan
Organization:
National Defense Medical Center Taiwan
Study Overview
Official Title:
Postoperative Use of Bisphosphonates Reduces Adverse Outcome After Primary Total Joint Arthroplasty A Nationwide Population-based Cohort Study
Status:
COMPLETED
Status Verified Date:
2022-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background Bisphosphonates has been associated with a decreased risk of revision total joint replacements because of its effects on decreased periprosthetic bone loss and prosthetic migration However the results in the early literature are inconsistent and the influence of bisphosphonates on associated complications and subsequent total joint arthroplasty TJA remains unknown This study is to investigate the association between the use of bisphosphonates and risk of adverse outcomes after primary TJA
Materials and Methods This matched cohort study utilized National Health Insurance Research Database in Taiwan to identify patients who underwent primary TJA over a 15-year period January 2000- December 2015 inclusive Study participants were further categorized into two groups bisphosphonates users and nonusers using propensity score matching The Kaplan-Meier curve analysis and adjusted hazard ratios aHR of revision surgery adverse outcomes of primary surgery and undergoing subsequent TJA were calculated using Cox regression analysis
Materials and Methods This matched cohort study utilized National Health Insurance Research Database in Taiwan to identify patients who underwent primary TJA over a 15-year period January 2000- December 2015 inclusive Study participants were further categorized into two groups bisphosphonates users and nonusers using propensity score matching The Kaplan-Meier curve analysis and adjusted hazard ratios aHR of revision surgery adverse outcomes of primary surgery and undergoing subsequent TJA were calculated using Cox regression analysis
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None