Ignite Creation Date:
2024-05-05 @ 6:37 PM
Last Modification Date:
2024-10-26 @ 9:35 AM
Study NCT ID:
NCT00519103
Status:
COMPLETED
Last Update Posted:
2007-08-30
First Post:
2007-08-20
Brief Title:
Resistance Exercise Reduces the Expression of Inflammation and Fibrosis Associated Genes in Autoimmune Myositis Patients
Sponsor:
Karolinska Institutet
Organization:
Karolinska Institutet
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2007-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study was to investigate the effects of physical exercise on gene expression in muscle biopsies from patients with chronic polymyositis or dermatomyositis
Detailed Description:
Eight patients with polymyositis or dermatomyositis according to the Bohan and Peter criteria and who had all participated in a resistive exercise trial at Karolinska University Hospital Stockholm Sweden were included in this study Patients were included if they had a disease duration more than 12 months and they had to have a stable low disease activity and medication for three months before enrollment in the study Patients with inclusion body myositis were excluded as well as patients with co morbidities that contradicted vigorous exercise severe osteoporosis with multiple fractures malignant disease severe lung disease or if they were physically active more than once a week The median disease duration at time of study start was 45 years range 27-29 year All patients had been treated with glucocorticoids and other immunosuppressive therapies with some improvement of muscle function but with persisting muscle impairment At time of study seven patients were still on immunosuppressive treatment five were taking prednisone with a median dosage of 25 mgday range 0-625 mgd Six patients were treated with azathioprine one in combination with cyclosporine A one patient was treated with methotrexate and one with IVIG 2gkg body weight every three months
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None