Viewing Study NCT05590858



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Last Modification Date: 2024-10-26 @ 2:44 PM
Study NCT ID: NCT05590858
Status: COMPLETED
Last Update Posted: 2022-10-21
First Post: 2022-10-19

Brief Title: Glycemic Control on Coronary Inflammation Evaluated by FAI in ACS
Sponsor: RenJi Hospital
Organization: RenJi Hospital

Study Overview

Official Title: Impact of Glycemic Control on Coronary Inflammation Evaluated by Computed Tomography Pericoronary Fat Attenuation Index in Patients With Acute Coronary Syndrome
Status: COMPLETED
Status Verified Date: 2022-10
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: This study aimed to clarify the relationship between blood glucose control and the FAI based pericoronary inflammation in low-risk ACS patients with or without diabetes The results of this study are expected to provide evidence that quantitative assessment of pericoronary FAI helps monitor the local inflammatory activation in diabetic patients with poor glycemic control therefore pericoronary FAI evaluation as a noninvasive imaging biomarker plays an important role in early detecting coronary atherosclerosis risk in diabetes and allow timely providing appropriate risk reduction strategies in patients at high risk for future cardiovascular events
Detailed Description: Coronary inflammation has been shown to be a cause of the significantly increased risk of cardiovascular disease CVD in diabetic patients This study aimed to investigate the relationship between coronary local inflammation detected by pericoronary fat attenuation index FAI and different blood glucose control levels in low-risk acute coronary syndrome ACS patients with or without diabetesA total of 309 patients with low-risk ACS were included in the analysis Patients were classified into three groups non-diabetes well-regulated diabetes and poorly regulated diabetes depend on the presence or absence of diabetes and the glycemic control evaluated based on a target HbA1c value of 7 Pericoronary FAI around the proximal of left anterior descending artery LAD left circumflex artery LCX and right coronary artery RCA were evaluated by CCTA while systemic inflammatory variables and other biochemical indicators were detected by flow cytometry The results of this study are expected to provide evidence that quantitative assessment of pericoronary FAI helps monitor the local inflammatory activation in diabetic patients with poor glycemic control therefore pericoronary FAI evaluation as a noninvasive imaging biomarker plays an important role in early detecting coronary atherosclerosis risk in diabetes and allow timely providing appropriate risk reduction strategies in patients at high risk for future cardiovascular events

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None