Ignite Creation Date:
2024-05-06 @ 6:14 PM
Last Modification Date:
2024-10-26 @ 2:44 PM
Study NCT ID:
NCT05589402
Status:
RECRUITING
Last Update Posted:
2024-01-18
First Post:
2022-06-23
Brief Title:
Temporary Inactivation of Strong Muscle Sensation to Improve Rehabilitation Interventions in SCI
Sponsor:
University of Texas Rio Grande Valley
Organization:
University of Texas Rio Grande Valley
Study Overview
Official Title:
Temporary Inactivation of Strong Muscle Sensation to Improve Rehabilitation Interventions in SCI
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators are conducting a research study to try to improve rehabilitation interventions for individuals with spinal cord injury SCI In this study the aim is to determine if temporarily numbing non-paralyzed arm muscles with an over-the-counter numbing cream while exercising paralyzed muscles can improve the strength function and sensation of paralyzed muscles after a spinal cord injury
Detailed Description:
The functional benefits of temporary deafferentation numbing-induced cortical plasticity have been demonstrated in individuals with stroke nerve damage and pain syndromes Of note documented benefits have included improvements in motor function and touch perception in the weaker muscles For example Weiss et al demonstrated that temporary deafferentation to the forearm of the paretic limb in stroke for two hours during movement therapy improved motor performance of the hand by 10 to 48 after a single session Another study established that bi-weekly sessions of temporary deafferentation for two weeks improved two-point discrimination and touch perception in individuals with ulnarmedian nerve damage More importantly the authors found that improvements were retained for more than four weeks after the intervention ended Collectively this suggests that the release of tonic inhibition on weak muscle pathways through temporary deafferentation can lead to functional benefits that are retained long-term
The Investigators pilot findings indicate that temporary deafferentation shows similar benefits in the population of SCI Specifically it was observed that a single 30-minute session of temporary deafferentation to the stronger biceps can improve excitability to the weaker triceps and result in gains in hand dexterity and pinch strength in SCI
The Investigators now seek to optimize the current study protocol before a large-scale clinical trial is conducted
The Investigators pilot findings indicate that temporary deafferentation shows similar benefits in the population of SCI Specifically it was observed that a single 30-minute session of temporary deafferentation to the stronger biceps can improve excitability to the weaker triceps and result in gains in hand dexterity and pinch strength in SCI
The Investigators now seek to optimize the current study protocol before a large-scale clinical trial is conducted
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None