Ignite Creation Date:
2024-05-05 @ 6:37 PM
Last Modification Date:
2024-10-26 @ 9:35 AM
Study NCT ID:
NCT00512369
Status:
TERMINATED
Last Update Posted:
2011-07-18
First Post:
2007-08-03
Brief Title:
Effects of PA-1 Transcriptional Regulation on Monocyte Function
Sponsor:
Vanderbilt University
Organization:
Vanderbilt University
Study Overview
Official Title:
Angiotensin the Vascular Endothelium and Fibrinolysis - The Effects of PAI-1 Transcriptional Regulation on Human Monocyte Function
Status:
TERMINATED
Status Verified Date:
2011-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Investigator left institution
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Researching genetic differences in people with no prior medical conditions for better understanding of cardiac diseases through genetic research
Detailed Description:
The discovery and subsequent application of small interfering RNA siRNA methods to achieve individual gene silencing in mammalian cells is a robust method that is well-described and validated in mammalian cell culture systems We will apply this technique to achieve post-transcriptional silencing of PAI-1 in monocytes obtained from otherwise healthy volunteers and study the subsequent loss of this genes function on the migratory capacity of these cells in the proposed in vitro experimental system This concept has not yet been demonstrated in the literature and if validated would be a novel and fundamental description of the role of PAI-1 in human monocyte biology as related to the development of atherosclerosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIH | None | None | None |