Ignite Creation Date:
2024-05-05 @ 9:53 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004326
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
1999-10-18
Brief Title:
Hippocampal Complex Volume and Memory Dysfunction in Cushings Syndrome
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2002-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES I Evaluate whether chronic hypercortisolemia is specifically toxic to hippocampal cells and causes structural reduction of hippocampal volume in patients with Cushings syndrome
II Determine whether reduced hippocampal volume is associated with specific memory dysfunction
III Examine the relationships of adrenal androgen to hippocampal volume and memory dysfunction
IV Examine the reversibility of hippocampal structural changes and cognitive dysfunction after cortisol levels are normalized
II Determine whether reduced hippocampal volume is associated with specific memory dysfunction
III Examine the relationships of adrenal androgen to hippocampal volume and memory dysfunction
IV Examine the reversibility of hippocampal structural changes and cognitive dysfunction after cortisol levels are normalized
Detailed Description:
PROTOCOL OUTLINE Patients undergo a psychiatric evaluation for mood and cognition during confirmation of diagnosis Neuropsychologic exams include pencil and paper test and a cognitive assessment
Endocrine studies include dexamethasone and corticotropin-releasing hormone stimulation tests The hippocampal complex volume is assessed with coronal magnetic resonance imaging
There is a follow-up 1 year after the initiation of treatment
Endocrine studies include dexamethasone and corticotropin-releasing hormone stimulation tests The hippocampal complex volume is assessed with coronal magnetic resonance imaging
There is a follow-up 1 year after the initiation of treatment
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| UMMC-1043 | None | None | None |